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- W2022309955 abstract "The tuber of Icacina trichantha was extracted with 50% methanol and concentrated to dryness in vacuo to give a yield of 5.6% w/w. The extract induced sleep in rats treated with high doses (400–1000 mg/kg i.p.). The LD50 of the extract was 671 mg/kg i.p. It potentiated pentobarbitone sleeping time in rats dose-dependently and also induced significant local anaesthetic effects in guinea-pigs. The extract was able to give 80% protection to rats poisoned with pentylenetetrazole but failed to protect rats from strychinine poisoning. It induced significant dose-dependent analgesia in rats and showed significant muscle relaxant activity in mice." @default.
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- W2022309955 date "1995-02-01" @default.
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- W2022309955 title "The effects ofIcacina trichantha tuber extract on the nervous system" @default.
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- W2022309955 doi "https://doi.org/10.1002/ptr.2650090106" @default.
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