Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022311911> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2022311911 endingPage "16" @default.
- W2022311911 startingPage "7" @default.
- W2022311911 abstract "Since reductions in cardiac high-energy phosphate content and dysfunction of mitochondrial activities have been demonstrated after doxorubicin exposure, one mechanism of doxorubicin cardiotoxicity has been thought to be an interference with mitochondrial energy metabolism. To determine whether mitochondrial dysfunction is induced by acute drug exposure, isolated rat hearts were perfused with 10(-5) M doxorubicin for 70 min followed by mitochondrial isolation. Rates of electron transport, creatine kinase activity, acceptor control, respiratory control, and ADP/O ratios were assayed and correlated to doxorubicin-induced abnormalities in left ventricular function. At doses of doxorubicin sufficient to cause a marked deterioration of left ventricular systolic pressure and a rise in end-diastolic pressure, no decreases were noted in the measured mitochondrial parameters with either glutamate plus malate or succinate as respiratory substrates. In fact, in some cases the rates of electron transport were higher in mitochondria isolated from the treated hearts. In addition, isolated heart mitochondria were directly incubated in doxorubicin at doses as high as 10(-4) M for up to 70 min at 0 and 20 degrees C and 1.5 min at 37 degrees C. Under these conditions functional impairment of mitochondrial respiration was also not detected. Therefore, it appears that acute doxorubicin cardiotoxicity cannot be related to primary mitochondrial defects in high-energy phosphate metabolism. These data lend further support to the notion that doxorubicin cardiotoxicity may be fundamentally related to changes in coronary vascular resistance and resultant damage induced by hypoperfusion." @default.
- W2022311911 created "2016-06-24" @default.
- W2022311911 creator A5032312523 @default.
- W2022311911 creator A5045507690 @default.
- W2022311911 creator A5050107961 @default.
- W2022311911 creator A5081805803 @default.
- W2022311911 date "1988-05-01" @default.
- W2022311911 modified "2023-09-23" @default.
- W2022311911 title "Absence of Acute Doxorubicin-Induced Dysfunction of Heart Mitochondrial Oxidative Phosphorylation and Creatine Kinase Activities" @default.
- W2022311911 doi "https://doi.org/10.3181/00379727-188-42699" @default.
- W2022311911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2897125" @default.
- W2022311911 hasPublicationYear "1988" @default.
- W2022311911 type Work @default.
- W2022311911 sameAs 2022311911 @default.
- W2022311911 citedByCount "11" @default.
- W2022311911 crossrefType "journal-article" @default.
- W2022311911 hasAuthorship W2022311911A5032312523 @default.
- W2022311911 hasAuthorship W2022311911A5045507690 @default.
- W2022311911 hasAuthorship W2022311911A5050107961 @default.
- W2022311911 hasAuthorship W2022311911A5081805803 @default.
- W2022311911 hasConcept C126322002 @default.
- W2022311911 hasConcept C134018914 @default.
- W2022311911 hasConcept C185592680 @default.
- W2022311911 hasConcept C2776694085 @default.
- W2022311911 hasConcept C2778233292 @default.
- W2022311911 hasConcept C2779896295 @default.
- W2022311911 hasConcept C2781303535 @default.
- W2022311911 hasConcept C28859421 @default.
- W2022311911 hasConcept C29730261 @default.
- W2022311911 hasConcept C3020377403 @default.
- W2022311911 hasConcept C36880943 @default.
- W2022311911 hasConcept C55493867 @default.
- W2022311911 hasConcept C57600042 @default.
- W2022311911 hasConcept C71924100 @default.
- W2022311911 hasConcept C86803240 @default.
- W2022311911 hasConcept C98274493 @default.
- W2022311911 hasConceptScore W2022311911C126322002 @default.
- W2022311911 hasConceptScore W2022311911C134018914 @default.
- W2022311911 hasConceptScore W2022311911C185592680 @default.
- W2022311911 hasConceptScore W2022311911C2776694085 @default.
- W2022311911 hasConceptScore W2022311911C2778233292 @default.
- W2022311911 hasConceptScore W2022311911C2779896295 @default.
- W2022311911 hasConceptScore W2022311911C2781303535 @default.
- W2022311911 hasConceptScore W2022311911C28859421 @default.
- W2022311911 hasConceptScore W2022311911C29730261 @default.
- W2022311911 hasConceptScore W2022311911C3020377403 @default.
- W2022311911 hasConceptScore W2022311911C36880943 @default.
- W2022311911 hasConceptScore W2022311911C55493867 @default.
- W2022311911 hasConceptScore W2022311911C57600042 @default.
- W2022311911 hasConceptScore W2022311911C71924100 @default.
- W2022311911 hasConceptScore W2022311911C86803240 @default.
- W2022311911 hasConceptScore W2022311911C98274493 @default.
- W2022311911 hasIssue "1" @default.
- W2022311911 hasLocation W20223119111 @default.
- W2022311911 hasLocation W20223119112 @default.
- W2022311911 hasOpenAccess W2022311911 @default.
- W2022311911 hasPrimaryLocation W20223119111 @default.
- W2022311911 hasRelatedWork W1983403995 @default.
- W2022311911 hasRelatedWork W1999365377 @default.
- W2022311911 hasRelatedWork W2019513797 @default.
- W2022311911 hasRelatedWork W2022311911 @default.
- W2022311911 hasRelatedWork W2035056608 @default.
- W2022311911 hasRelatedWork W2138552465 @default.
- W2022311911 hasRelatedWork W2158491319 @default.
- W2022311911 hasRelatedWork W2421641992 @default.
- W2022311911 hasRelatedWork W2512465485 @default.
- W2022311911 hasRelatedWork W2754293311 @default.
- W2022311911 hasVolume "188" @default.
- W2022311911 isParatext "false" @default.
- W2022311911 isRetracted "false" @default.
- W2022311911 magId "2022311911" @default.
- W2022311911 workType "article" @default.