Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022311923> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2022311923 endingPage "130" @default.
- W2022311923 startingPage "126" @default.
- W2022311923 abstract "The aim of this study was to evaluate the objective tumor response rates and toxicities in elderly patients (older than 70 years) with advanced colorectal cancer treated with 5-fluorouracil (5-FU) as a first-line palliative chemotherapy regimen. Eighty-six consecutive patients were enrolled onto a retrospective study between January 1990 and February 1998. Patients were divided into two groups; group 1 consisted of patients who were 70 to 74 years old, and group 2 consisted of patients who were age 75 years and older. Four types of 5-FU-based chemotherapy were administered. First-line chemotherapy was continued until disease progression, unacceptable toxicity, or patient refusal. Primary tumor sites were the colon (n = 44), rectum (n = 29), and colorectal (n = 13). There was no difference in response (complete/partial) rates according to age groups (group 1: 21%, group 2: 26%). Median overall survival was 17 months for group 1 and 14 months for group 2, with 1-year survival at 63% and 55%, respectively (not statistically significant). Median time to progression was 6 months for both age groups. Chemotherapy in both groups increased performance status, and weight in 26% and 31%, respectively. No toxic death was reported. There was no difference in overall or severe toxicity between the two age groups, and all adverse events were manageable. Toxicity (grade III/IV) occurred in 25% of patients. Based on these findings, palliative first-line chemotherapy for colorectal cancer can be performed in selected elderly patients without increasing either morbidity or mortality, while obtaining response rates and side effects comparable to those in younger patients." @default.
- W2022311923 created "2016-06-24" @default.
- W2022311923 creator A5013758047 @default.
- W2022311923 creator A5032686530 @default.
- W2022311923 creator A5052299853 @default.
- W2022311923 creator A5052430948 @default.
- W2022311923 creator A5064590930 @default.
- W2022311923 creator A5066162032 @default.
- W2022311923 creator A5081573158 @default.
- W2022311923 date "2002-04-01" @default.
- W2022311923 modified "2023-10-12" @default.
- W2022311923 title "Palliative 5-Fluorouracil-Based Chemotherapy for Advanced Colorectal Cancer in the Elderly" @default.
- W2022311923 cites W1902766545 @default.
- W2022311923 cites W1941365207 @default.
- W2022311923 cites W1982848233 @default.
- W2022311923 cites W1995689784 @default.
- W2022311923 cites W2061006522 @default.
- W2022311923 cites W2089612100 @default.
- W2022311923 cites W2093036179 @default.
- W2022311923 cites W2179790211 @default.
- W2022311923 cites W2217081518 @default.
- W2022311923 cites W4244082907 @default.
- W2022311923 doi "https://doi.org/10.1097/00000421-200204000-00005" @default.
- W2022311923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11943888" @default.
- W2022311923 hasPublicationYear "2002" @default.
- W2022311923 type Work @default.
- W2022311923 sameAs 2022311923 @default.
- W2022311923 citedByCount "40" @default.
- W2022311923 countsByYear W20223119232013 @default.
- W2022311923 countsByYear W20223119232014 @default.
- W2022311923 countsByYear W20223119232015 @default.
- W2022311923 countsByYear W20223119232016 @default.
- W2022311923 countsByYear W20223119232017 @default.
- W2022311923 countsByYear W20223119232018 @default.
- W2022311923 countsByYear W20223119232020 @default.
- W2022311923 countsByYear W20223119232022 @default.
- W2022311923 crossrefType "journal-article" @default.
- W2022311923 hasAuthorship W2022311923A5013758047 @default.
- W2022311923 hasAuthorship W2022311923A5032686530 @default.
- W2022311923 hasAuthorship W2022311923A5052299853 @default.
- W2022311923 hasAuthorship W2022311923A5052430948 @default.
- W2022311923 hasAuthorship W2022311923A5064590930 @default.
- W2022311923 hasAuthorship W2022311923A5066162032 @default.
- W2022311923 hasAuthorship W2022311923A5081573158 @default.
- W2022311923 hasConcept C121608353 @default.
- W2022311923 hasConcept C126322002 @default.
- W2022311923 hasConcept C141071460 @default.
- W2022311923 hasConcept C159110408 @default.
- W2022311923 hasConcept C167135981 @default.
- W2022311923 hasConcept C2776694085 @default.
- W2022311923 hasConcept C2776907518 @default.
- W2022311923 hasConcept C2778336483 @default.
- W2022311923 hasConcept C2780456651 @default.
- W2022311923 hasConcept C2781074409 @default.
- W2022311923 hasConcept C2781413609 @default.
- W2022311923 hasConcept C29730261 @default.
- W2022311923 hasConcept C2994186709 @default.
- W2022311923 hasConcept C526805850 @default.
- W2022311923 hasConcept C71924100 @default.
- W2022311923 hasConcept C90924648 @default.
- W2022311923 hasConceptScore W2022311923C121608353 @default.
- W2022311923 hasConceptScore W2022311923C126322002 @default.
- W2022311923 hasConceptScore W2022311923C141071460 @default.
- W2022311923 hasConceptScore W2022311923C159110408 @default.
- W2022311923 hasConceptScore W2022311923C167135981 @default.
- W2022311923 hasConceptScore W2022311923C2776694085 @default.
- W2022311923 hasConceptScore W2022311923C2776907518 @default.
- W2022311923 hasConceptScore W2022311923C2778336483 @default.
- W2022311923 hasConceptScore W2022311923C2780456651 @default.
- W2022311923 hasConceptScore W2022311923C2781074409 @default.
- W2022311923 hasConceptScore W2022311923C2781413609 @default.
- W2022311923 hasConceptScore W2022311923C29730261 @default.
- W2022311923 hasConceptScore W2022311923C2994186709 @default.
- W2022311923 hasConceptScore W2022311923C526805850 @default.
- W2022311923 hasConceptScore W2022311923C71924100 @default.
- W2022311923 hasConceptScore W2022311923C90924648 @default.
- W2022311923 hasIssue "2" @default.
- W2022311923 hasLocation W20223119231 @default.
- W2022311923 hasLocation W20223119232 @default.
- W2022311923 hasOpenAccess W2022311923 @default.
- W2022311923 hasPrimaryLocation W20223119231 @default.
- W2022311923 hasRelatedWork W196651854 @default.
- W2022311923 hasRelatedWork W1969825132 @default.
- W2022311923 hasRelatedWork W2007490384 @default.
- W2022311923 hasRelatedWork W2041959407 @default.
- W2022311923 hasRelatedWork W2069533287 @default.
- W2022311923 hasRelatedWork W2157260450 @default.
- W2022311923 hasRelatedWork W2986779194 @default.
- W2022311923 hasRelatedWork W3029625970 @default.
- W2022311923 hasRelatedWork W3173830799 @default.
- W2022311923 hasRelatedWork W2993882870 @default.
- W2022311923 hasVolume "25" @default.
- W2022311923 isParatext "false" @default.
- W2022311923 isRetracted "false" @default.
- W2022311923 magId "2022311923" @default.
- W2022311923 workType "article" @default.