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• W2022320617 abstract "You have accessJournal of UrologyBladder Cancer: Basic Research1 Apr 2011519 DIAGNOSTIC AND PROGNOSTIC VALUE OF BLADDER CANCER-RELATED TRANSCRIPT MARKERS IN URINE Juliane Schmidt, Catharina Propping, Woei-Yun Siow, Susanne Fuessel, Andrea Lohse-Fischer, Marieta Toma, Anka Baldauf-Twelker, Oliver W. Hakenberg, and Manfred P. Wirth Juliane SchmidtJuliane Schmidt Dresden, Germany More articles by this author , Catharina ProppingCatharina Propping Dresden, Germany More articles by this author , Woei-Yun SiowWoei-Yun Siow Singapore, Singapore More articles by this author , Susanne FuesselSusanne Fuessel Dresden, Germany More articles by this author , Andrea Lohse-FischerAndrea Lohse-Fischer Dresden, Germany More articles by this author , Marieta TomaMarieta Toma Dresden, Germany More articles by this author , Anka Baldauf-TwelkerAnka Baldauf-Twelker Dresden, Germany More articles by this author , Oliver W. HakenbergOliver W. Hakenberg Rostock, Germany More articles by this author , and Manfred P. WirthManfred P. Wirth Dresden, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1215AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Since cytology, the current “gold standard” for non-invasive detection of bladder cancer (BCa), is characterized by a relatively low sensitivity, we evaluated different BCa-related biomarkers in urine specimens as an alternative or complementary technique to increase diagnostic power. Furthermore, we investigated their prognostic value by analyzing the correlation between the transcript level and the appearance of the first recurrence. METHODS Samples from 123 BCa patients were collected before primary transurethral resection of bladder tumor. Patients with benign prostatic hyperplasia (n=62), cystitis (n=25) and healthy volunteers (n=46) served as control groups. Total RNA was isolated from urine samples and reverse-transcribed into cDNA. Expression levels of survivin (SVV), XIAP, Ki67 and CK20 were determined by quantitative PCR and normalized to the housekeeping gene TBP. Sensitivity and specificity were calculated for the biomarkers as well as for cytology. A continuous follow-up was collected. RESULTS Receiver-operating-characteristic (ROC) analyses resulted in AUC-values of 0.71 (XIAP), 0.74 (Ki67), 0.82 (SVV) and 0.86 (CK20) indicating an appropriate diagnostic power. Using specifically defined cut-off values expression levels of the assessed biomarkers were significantly higher in BCa patients than in controls (Mann-Whitney-U-Test: p<0.001). Specificity ranged from 64% (XIAP) to 84% (CK20), sensitivity from 65% (XIAP) to 87% (CK20). In combination with cytology sensitivity increased up to 97% for CK20 as the best biomarker. With respect to the prognostic power of the markers, SVV was the only one that showed a significant correlation between the expression level at the beginning and an early recurrence during the first year after diagnosis of the BCa (p=0.042). CONCLUSIONS Quantitative assessment of tumor related biomarkers, particularly of CK20, is a non-invasive method to identify patients with BCa. Moreover, SVV appears to be useful as a prognostic marker for the identification of patients at high risk of recurrence. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e211 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Juliane Schmidt Dresden, Germany More articles by this author Catharina Propping Dresden, Germany More articles by this author Woei-Yun Siow Singapore, Singapore More articles by this author Susanne Fuessel Dresden, Germany More articles by this author Andrea Lohse-Fischer Dresden, Germany More articles by this author Marieta Toma Dresden, Germany More articles by this author Anka Baldauf-Twelker Dresden, Germany More articles by this author Oliver W. Hakenberg Rostock, Germany More articles by this author Manfred P. Wirth Dresden, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2022320617 title "519 DIAGNOSTIC AND PROGNOSTIC VALUE OF BLADDER CANCER-RELATED TRANSCRIPT MARKERS IN URINE" @default.
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