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- W2022320740 abstract "Alzheimer's disease (AD), the most common form of dementia, is characterized by extracellular plaques in the brain created when monomeric amyloid-β (Aβ) protein aggregates into fibrillar structures. Soluble Aβ aggregates, including oligomers that form along the reaction pathway, are believed to be the more toxic species and can increase the production of reactive oxygen species (ROS). Polyphenols have been suggested as a complimentary AD therapeutic based on epidemiological evidence that polyphenol-rich diets correlate with a reduced incidence of AD. In particular, many flavonoids, a subclass of polyphenols, have the ability to inhibit Aβ aggregation. Alternatively, polyphenols can counter Aβ-induced cellular responses by neutralizing ROS through their antioxidant properties. This study sought to identify polyphenols that can reduce Aβ-induced apoptosis by inhibiting Aβ aggregation and/or reducing ROS.Polyphenols investigated include quercetin (QUE), rhamnetin (RHA), isorhamnetin (IRHA), and tamarixetin (TAM). Using SDS-PAGE and Western blot to evaluate oligomer size, only IRHA was unable to reduce Aβ oligomers 250 – 100 kDa in size, while QUE reduced these oligomers by 88.3 ± 2.4%. All compounds reduced Aβ oligomers <100 kDa in size, although IRHA was still the weakest inhibitor. Antioxidant capabilities were quantified in vitro relative to Trolox, a vitamin E analog. All compounds tested exhibited antioxidant capability similar to Trolox. To assess the effect of anti-aggregation and antioxidant properties on Aβ-induced apoptosis, human neuroblastoma cells were stained using TUNEL, which identifies breaks in the DNA strand. Polyphenols with anti-aggregation properties successfully reduced apoptosis, and it is hypothesized that antioxidant activity will also have a protective effect." @default.
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- W2022320740 date "2015-01-01" @default.
- W2022320740 modified "2023-09-25" @default.
- W2022320740 title "The Ability of Polyphenols to Reduce Aβ-Induced Apoptosis Associated with Alzheimer's Disease" @default.
- W2022320740 doi "https://doi.org/10.1016/j.bpj.2014.11.392" @default.
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