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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022321294> ?p ?o ?g. }

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• W2022321294 abstract "The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts." @default.
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• W2022321294 date "2014-06-01" @default.
• W2022321294 modified "2023-09-27" @default.
• W2022321294 title "Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2" @default.
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• W2022321294 doi "https://doi.org/10.1016/j.bmcl.2014.04.068" @default.
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