FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022321370> ?p ?o ?g. }

• W2022321370 endingPage "71" @default.
• W2022321370 startingPage "63" @default.
• W2022321370 abstract "Multivariate methods are utilized to compare nicotinic acid and dihydropyridine as a drug carrier. Nicotinic acid and dihydropyridine form ester groups on 10 β-lactam antibiotics with an oxymethyl group forming a linkage between the antibiotic and the drug carrier (nicotinic acid or dihydropyridine). Calculated molecular properties are analyzed by self-organizing tree algorithm (SOTA), bivariate regression, cluster analysis, factor analysis, discriminant analysis, hierarchical classification, and principal coordinates analysis. Ten important pharmacological properties for each of the nicotinic acid and dihydropyridine antibiotic derivatives are numerically similar and highly correlated. Calculated molecular properties include molar refractivity, molar volume, parachor, index of refraction, partition coefficient (logP), polarizability, and polar surface area. Dermal permeability coefficients (Kp) for nicotinic acid derivatives are similar to values for dihydropyridine derivatives. Dermal permeabliity coefficients analyzed by hierarchical classification and SOTA analysis were shown to be closely interrelated and highly correlated. Ten properties of the nicotinic acid and dihydropyridine were compared by Passing–Bablok regression analysis and shown to be highly correlated (r=0.9879). Box plot analysis of 10 properties, inclusive of both groups of derivatives, showed narrow ranges in values. Cluster analysis of derivative properties showed the nicotinic acid derivatives to be highly similar to the dihydropyridine derivatives of the same antibiotics. Cluster analysis was performed by single linkage, complete linkage, and centroid linkage. Factor analysis showed the nicotinic acid derivatives to be interrelated and similar to the dihydropyridine derivatives. Discriminant analysis performed on all derivatives formed a single highly cohesive and non-differentiated cluster, demonstrating strong similarity among nicotinic acid and dihydropyridine derivatives. Principal coordinates analysis (determines similarity) of Kp values showed high similarity between the nicotinic acid and dihydropyridine antibiotic derivatives." @default.
• W2022321370 created "2016-06-24" @default.
• W2022321370 creator A5012875732 @default.
• W2022321370 date "2005-01-01" @default.
• W2022321370 modified "2023-10-04" @default.
• W2022321370 title "Applying pattern recognition methods and structure property correlations to determine drug carrier potential of nicotinic acid and analogize to dihydropyridine" @default.
• W2022321370 cites W1489601464 @default.
• W2022321370 cites W1836971294 @default.
• W2022321370 cites W1971932631 @default.
• W2022321370 cites W1985691179 @default.
• W2022321370 cites W1990057891 @default.
• W2022321370 cites W2015625626 @default.
• W2022321370 cites W2030949382 @default.
• W2022321370 cites W2033495141 @default.
• W2022321370 cites W2045589991 @default.
• W2022321370 cites W2045812803 @default.
• W2022321370 cites W2077213487 @default.
• W2022321370 cites W2091439659 @default.
• W2022321370 cites W2094750196 @default.
• W2022321370 cites W2134344823 @default.
• W2022321370 cites W2135791305 @default.
• W2022321370 cites W2137540340 @default.
• W2022321370 cites W2152578953 @default.
• W2022321370 cites W2155151696 @default.
• W2022321370 cites W2182593958 @default.
• W2022321370 cites W4248107770 @default.
• W2022321370 doi "https://doi.org/10.1016/j.ejpb.2004.05.003" @default.
• W2022321370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15567303" @default.
• W2022321370 hasPublicationYear "2005" @default.
• W2022321370 type Work @default.
• W2022321370 sameAs 2022321370 @default.
• W2022321370 citedByCount "3" @default.
• W2022321370 countsByYear W20223213702016 @default.
• W2022321370 crossrefType "journal-article" @default.
• W2022321370 hasAuthorship W2022321370A5012875732 @default.
• W2022321370 hasBestOaLocation W20223213701 @default.
• W2022321370 hasConcept C164126121 @default.
• W2022321370 hasConcept C170493617 @default.
• W2022321370 hasConcept C178790620 @default.
• W2022321370 hasConcept C185592680 @default.
• W2022321370 hasConcept C188987157 @default.
• W2022321370 hasConcept C207464780 @default.
• W2022321370 hasConcept C2780708107 @default.
• W2022321370 hasConcept C2781212610 @default.
• W2022321370 hasConcept C32909587 @default.
• W2022321370 hasConcept C519063684 @default.
• W2022321370 hasConcept C55493867 @default.
• W2022321370 hasConcept C71240020 @default.
• W2022321370 hasConceptScore W2022321370C164126121 @default.
• W2022321370 hasConceptScore W2022321370C170493617 @default.
• W2022321370 hasConceptScore W2022321370C178790620 @default.
• W2022321370 hasConceptScore W2022321370C185592680 @default.
• W2022321370 hasConceptScore W2022321370C188987157 @default.
• W2022321370 hasConceptScore W2022321370C207464780 @default.
• W2022321370 hasConceptScore W2022321370C2780708107 @default.
• W2022321370 hasConceptScore W2022321370C2781212610 @default.
• W2022321370 hasConceptScore W2022321370C32909587 @default.
• W2022321370 hasConceptScore W2022321370C519063684 @default.
• W2022321370 hasConceptScore W2022321370C55493867 @default.
• W2022321370 hasConceptScore W2022321370C71240020 @default.
• W2022321370 hasIssue "1" @default.
• W2022321370 hasLocation W20223213701 @default.
• W2022321370 hasLocation W20223213702 @default.
• W2022321370 hasOpenAccess W2022321370 @default.
• W2022321370 hasPrimaryLocation W20223213701 @default.
• W2022321370 hasRelatedWork W1984240915 @default.
• W2022321370 hasRelatedWork W2014131254 @default.
• W2022321370 hasRelatedWork W2017299903 @default.
• W2022321370 hasRelatedWork W2022321370 @default.
• W2022321370 hasRelatedWork W2042885419 @default.
• W2022321370 hasRelatedWork W2167806046 @default.
• W2022321370 hasRelatedWork W2756624910 @default.
• W2022321370 hasRelatedWork W4280549065 @default.
• W2022321370 hasRelatedWork W2184066525 @default.
• W2022321370 hasRelatedWork W2624273695 @default.
• W2022321370 hasVolume "59" @default.
• W2022321370 isParatext "false" @default.
• W2022321370 isRetracted "false" @default.
• W2022321370 magId "2022321370" @default.
• W2022321370 workType "article" @default.