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• W2022321609 abstract "Mesenchymal stem cells (MSCs) are considered to be one of the most promising therapeutic cell sources as they encompass a plasticity of multiple cell lineages. The challenge in using these cells lies in developing well-defined protocols for directing cellular differentiation to generate a desired lineage. In this study, we investigated the effect of 5-azacytidine, a DNA demethylating agent, on osteogenic differentiation of MSCs. The cells were exposed to 5-azacytidine in culture medium for 24 h prior to osteogenic induction. Osteogenic differentiation was determined by several the appearance of a number of osteogenesis characteristics, including gene expression, ALP activity, and calcium mineralization. Pretreatment of MSCs with 5-azacytidine significantly facilitated osteogenic differentiation and was accompanied by hypomethylation of genomic DNA and increased osteogenic gene expression. Taking dlx5 as a representative, methylation alterations of the CpG island shore in the promoter caused by 5-azacytidine appeared to contribute to osteogenic differentiation." @default.
• W2022321609 created "2016-06-24" @default.
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• W2022321609 date "2009-06-26" @default.
• W2022321609 modified "2023-09-25" @default.
• W2022321609 title "5-Azacytidine facilitates osteogenic gene expression and differentiation of mesenchymal stem cells by alteration in DNA methylation" @default.
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• W2022321609 doi "https://doi.org/10.1007/s10616-009-9203-2" @default.
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