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- W2022323100 abstract "1. When protoporphyrin is added to normal red cells it distributes to about 30% in the stroma and 70% in the cytosol. By comparison, in erythropoietic protoporphyria red cell protoporphyrin is found to more than 95% in the cytosol. 2. At equimolar concentrations of protoporphyrin the photohemolysis is much more severe in normal red cells with exogenous protoporphyrin than in red cells from patients with erythropoietic protoporphyria. 3. The photohemolysis is markedly enhanced when D2O is used as solvent instead of H2O. 4. The results suggest that the photodamage is determined by the ability of susceptible structures to accumulate porphyrins, the partition of porphyrins between lipophilic and hydrophilic structures and the longevity of singlet oxygen in lipophilic environments." @default.
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- W2022323100 title "Protoporphyrin-induced Photohemolysis : Differences related to the subcellular distribution of protoporphyrin in erythropoietic protoporphyria and when added to normal red cells" @default.
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