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• W2022325044 startingPage "295" @default.
• W2022325044 abstract "This review examines the biological significance, therapeutic potential and mechanism(s) of action of a range of nitric oxide‐releasing non‐steroidal anti‐inflammatory drugs (NO‐NSAID) and related nitric oxide‐releasing donating drugs (NODD). The slow release of nitric oxide (NO) from these compounds leads to subtle changes in the profile of pharmacological activity of the parent, non‐steroidal anti‐inflammatory drugs (NSAID). For example, compared with NSAID, NO‐NSAID cause markedly diminished gastrointestinal toxicity and improved anti‐inflammatory and anti‐nociceptive efficacy. In addition, nitroparacetamol exhibits hepatoprotection as opposed to the hepatotoxic activity of paracetamol. The possibility that NO‐NSAID or NODD may be of therapeutic benefit in a wide variety of disease states including pain and inflammation, thrombosis and restenosis, neurodegenerative diseases of the central nervous system, colitis, cancer, urinary incontinence, liver disease, impotence, bronchial asthma and osteoporosis is discussed. British Journal of Pharmacology (2002) 137 , 295–310. doi: 10.1038/sj.bjp.0704876" @default.
• W2022325044 created "2016-06-24" @default.
• W2022325044 creator A5002942595 @default.
• W2022325044 creator A5013291347 @default.
• W2022325044 date "2002-10-01" @default.
• W2022325044 modified "2023-10-14" @default.
• W2022325044 title "Pharmacology and potential therapeutic applications of nitric oxide‐releasing non‐steroidal anti‐inflammatory and related nitric oxide‐donating drugs" @default.
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