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• W2022327888 abstract "The gene for tryptophan oxygenase (TO) is expressed in adult hepatocytes in a tissue- and differentiation-specific manner. The TO promoter has two glucocorticoid-responsive elements (GREs), and its expression is regulated by glucocorticoid hormone in the liver. We found a novel GRE in close proximity to a scaffold/matrix attachment region (S/MAR) that was located around −8.5 kb from the transcriptional start site of the TO gene by electrophoretic mobility shift and chromatin immunoprecipitation (ChIP) assays. A combination of nuclear fractionation and quantitative PCR analysis showed that the S/MAR was tethered to the nuclear matrix in both fetal and adult hepatocytes. ChIP assay showed that, in adult hepatocytes, the S/MAR-GRE and the promoter proximal regions interacted with lamin and heterogeneous nuclear ribonucleoprotein U in a dexamethasone dependent manner, but this was not the case in fetal cells, suggesting that developmental stage-specific expression of the TO gene might rely on the binding of the enhancer (the −8.5 kb S/MAR-GRE) and the promoter to the inner nuclear matrix." @default.
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• W2022327888 date "2009-10-01" @default.
• W2022327888 modified "2023-09-26" @default.
• W2022327888 title "Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene" @default.
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• W2022327888 doi "https://doi.org/10.1016/j.bbrc.2009.07.095" @default.
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