Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022331911> ?p ?o ?g. }
- W2022331911 endingPage "474" @default.
- W2022331911 startingPage "457" @default.
- W2022331911 abstract "Nucleic acid interaction with nanoscale objects like carbon nanotubes (CNTs) and dendrimers is of fundamental interest because of their potential application in CNT separation, gene therapy and antisense therapy. Combining nucleic acids with CNTs and dendrimers also opens the door towards controllable self-assembly to generate various supra-molecular and nano-structures with desired morphologies. The interaction between these nanoscale objects also serve as a model system for studying DNA compaction, which is a fundamental process in chromatin organization. By using fully atomistic simulations, here we report various aspects of the interactions and binding modes of DNA and small interfering RNA (siRNA) with CNTs, graphene and dendrimers. Our results give a microscopic picture and mechanism of the adsorption of single- and double-strand DNA (ssDNA and dsDNA) on CNT and graphene. The nucleic acid–CNT interaction is dominated by the dispersive van der Waals (vdW) interaction. In contrast, the complexation of DNA (both ssDNA and dsDNA) and siRNA with various generations of poly-amido-amine (PAMAM) dendrimers is governed by electrostatic interactions. Our results reveal that both the DNA and siRNA form stable complex with the PAMAM dendrimer at a physiological pH when the dendrimer is positively charged due to the protonation of the primary amines. The size and binding energy of the complex increase with increase in dendrimer generation. We also give a summary of the current status in these fields and discuss future prospects." @default.
- W2022331911 created "2016-06-24" @default.
- W2022331911 creator A5045956524 @default.
- W2022331911 creator A5057268093 @default.
- W2022331911 creator A5074647831 @default.
- W2022331911 date "2012-06-26" @default.
- W2022331911 modified "2023-09-23" @default.
- W2022331911 title "Interaction of nucleic acids with carbon nanotubes and dendrimers" @default.
- W2022331911 cites W1488192195 @default.
- W2022331911 cites W1605738254 @default.
- W2022331911 cites W1611419331 @default.
- W2022331911 cites W1647075334 @default.
- W2022331911 cites W1939421214 @default.
- W2022331911 cites W1964034127 @default.
- W2022331911 cites W1965333215 @default.
- W2022331911 cites W1974455466 @default.
- W2022331911 cites W1975580333 @default.
- W2022331911 cites W1976060898 @default.
- W2022331911 cites W1978482484 @default.
- W2022331911 cites W1981482769 @default.
- W2022331911 cites W1981950313 @default.
- W2022331911 cites W1984071764 @default.
- W2022331911 cites W1989454102 @default.
- W2022331911 cites W1989703806 @default.
- W2022331911 cites W1989856919 @default.
- W2022331911 cites W1992620470 @default.
- W2022331911 cites W1993227183 @default.
- W2022331911 cites W1994736624 @default.
- W2022331911 cites W1996545689 @default.
- W2022331911 cites W1998372363 @default.
- W2022331911 cites W1998697301 @default.
- W2022331911 cites W2002903271 @default.
- W2022331911 cites W2004518911 @default.
- W2022331911 cites W2009581957 @default.
- W2022331911 cites W2010163828 @default.
- W2022331911 cites W2014935324 @default.
- W2022331911 cites W2018593147 @default.
- W2022331911 cites W2019985255 @default.
- W2022331911 cites W2022889126 @default.
- W2022331911 cites W2023104469 @default.
- W2022331911 cites W2027945440 @default.
- W2022331911 cites W2030773205 @default.
- W2022331911 cites W2031807994 @default.
- W2022331911 cites W2035467907 @default.
- W2022331911 cites W2037272488 @default.
- W2022331911 cites W2040044589 @default.
- W2022331911 cites W2046500362 @default.
- W2022331911 cites W2047328569 @default.
- W2022331911 cites W2048724743 @default.
- W2022331911 cites W2052079189 @default.
- W2022331911 cites W2052312685 @default.
- W2022331911 cites W2053918681 @default.
- W2022331911 cites W2054688134 @default.
- W2022331911 cites W2058122340 @default.
- W2022331911 cites W2061553428 @default.
- W2022331911 cites W2062810119 @default.
- W2022331911 cites W2069123478 @default.
- W2022331911 cites W2071775762 @default.
- W2022331911 cites W2073091925 @default.
- W2022331911 cites W2077325967 @default.
- W2022331911 cites W2080474359 @default.
- W2022331911 cites W2080575130 @default.
- W2022331911 cites W2080823739 @default.
- W2022331911 cites W2082157760 @default.
- W2022331911 cites W2083280988 @default.
- W2022331911 cites W2086359820 @default.
- W2022331911 cites W2090858729 @default.
- W2022331911 cites W2091211551 @default.
- W2022331911 cites W2092049057 @default.
- W2022331911 cites W2092536024 @default.
- W2022331911 cites W2093515163 @default.
- W2022331911 cites W2093554913 @default.
- W2022331911 cites W2093840353 @default.
- W2022331911 cites W2097778157 @default.
- W2022331911 cites W2101673712 @default.
- W2022331911 cites W2101977779 @default.
- W2022331911 cites W2105685140 @default.
- W2022331911 cites W2112126991 @default.
- W2022331911 cites W2115202843 @default.
- W2022331911 cites W2116424844 @default.
- W2022331911 cites W2117040422 @default.
- W2022331911 cites W2117208578 @default.
- W2022331911 cites W2118492507 @default.
- W2022331911 cites W2121297333 @default.
- W2022331911 cites W2122682017 @default.
- W2022331911 cites W2126466006 @default.
- W2022331911 cites W2127497651 @default.
- W2022331911 cites W2132262459 @default.
- W2022331911 cites W2137605538 @default.
- W2022331911 cites W2152993806 @default.
- W2022331911 cites W2159955926 @default.
- W2022331911 cites W2165243439 @default.
- W2022331911 cites W2167381746 @default.
- W2022331911 cites W2168442336 @default.
- W2022331911 cites W2175249821 @default.
- W2022331911 cites W2330127921 @default.
- W2022331911 cites W2616798345 @default.
- W2022331911 cites W280694366 @default.