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- W2022333322 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILSerum PG I and PG I /PGII levels seemed to be related to the functional changes in the stomach, and their use as ‘serological biopsy’ in gastric cancer and precancerous diseases has been reported over 20 years. But the dynamic expression of pepsinogen I in situ of gastric mucosa and the value to detect gastric cancer and precancerous diseases, relative to the serum pepsinogen I is still unclear. Helicobacter pylori is a gram-negative bacterium that colonizes the stomach. More than 50% of the adult population are infected with H. pylori worldwide. Numerous studies have reported that healthy volunteers and gastric ulcer patients with H pylori infection have increased serum pepsinogen I levels which decrease after H pylori eradication. The evidence whether expression of pepesinogen I in situ affected by H pylori infection is not available. We thus conducted this study to investigate the dynamic expression of pepsinogen I in superficial gastritis, atrophic gastritis, gastric cancer and also H.pylori-associated gastric lesions and evaluate the application value of pepsinogen I in classifying gastric cancer and its precancerous diseases, and also the influence of H pylori on pepsinogen I expression. The expression of pepsinogen I was determined by immunohistochemistry method in 185 cases with mucosa taken from gastric corpus as well as from antrum. H.pylori infection was determined by histological examination and ELISA. Serum pepsinogen I and II were determined by ELISA. We found that Pepsinogen I was only expressed in the gastric corpus. There were 185 cases from gastric corpus and the positive rate of pepsinogen I expression in superficial gastritis, atrophic gastritis and gastric cancer decreased significantly in sequence (P 0.05) and the ratio of sPGA to sPGC decreased along with the above groups. (P<0.05). In conclusion, expression of PGI in situ has positive correlation with the degree of malignancy of gastric mucosa. and it is good biomarker for the diagnosis of gastric cancer and precancerous diseases. Also, The expression of PGI has positive correlation with H.pylori infection, and maybe is an important part in the H pylori- related damage or a good marker for screening H.pylori infection.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3606. doi:1538-7445.AM2012-3606" @default.
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- W2022333322 date "2012-04-15" @default.
- W2022333322 modified "2023-09-22" @default.
- W2022333322 title "Abstract 3606: Dynamic expression of pepsinogen I in gastric diseases sequence and relationship with Helicobacter pylori infection" @default.
- W2022333322 doi "https://doi.org/10.1158/1538-7445.am2012-3606" @default.
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