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- W2022333446 abstract "We report that peripheral nerves have a functional adenylate cyclase-coupled beta-adrenergic receptor. The pharmacological specificity of this receptor is shown to be of the beta 2 subtype. Two peripheral nerves, the sciatic from the frog and rat and the vagus from the rat, responded to beta 2-agonists with 10-50-fold increases in intracellular cyclic AMP level. This increase was inhibited by the beta-adrenergic antagonist propranolol. In contrast, a central nerve tract, the corpus callosum, responded to isoproterenol with only a minimal one- to twofold increase in cyclic AMP level. These studies demonstrate that peripheral nerves have beta 2-adrenergic receptors that are responsive to exogenously applied catecholamines and suggest a role for these ligands in the previously described modulation of axonal conduction." @default.
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- W2022333446 date "1986-01-01" @default.
- W2022333446 modified "2023-09-28" @default.
- W2022333446 title "?<sub>2</sub>-Adrenergic Receptors on Peripheral Nerves" @default.
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- W2022333446 doi "https://doi.org/10.1111/j.1471-4159.1986.tb12961.x" @default.
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