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- W2022333496 abstract "The release of antimicrobial peptides and growth factors by Paneth cells is thought to play an important role in protecting the small intestine, but the mechanisms involved have remained obscure. Immunohistochemistry and immunofluorescence showed that Paneth cells express Toll-like receptor 9 (TLR9) in the granules. Injection of mice with oligonucleotides containing CpG sequence (CpG-ODNs) led to a down-modulation of TLR9 and a striking decrease in the number of large secretory granules, consistent with degranulation. Moreover CpG-ODN treatment increased resistance to oral challenge with virulent Salmonella typhimurium. Moreover, our findings demonstrate a sentinel role for Paneth cells through TLR9." @default.
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- W2022333496 date "2004-08-01" @default.
- W2022333496 modified "2023-10-17" @default.
- W2022333496 title "Degranulation of Paneth Cells via Toll-Like Receptor 9" @default.
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- W2022333496 doi "https://doi.org/10.1016/s0002-9440(10)63304-4" @default.
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