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- W2022335967 abstract "Serum dimethadione (DMO)/trimethadione (TMO) ratios after oral administration of TMO have been investigated in 10 patients with normal livers, 8 patients with hepatoma and 8 patients with hepatoma and cirrhosis. Serum concentration ratios of DMO to TMO at 4 h after oral administration of TMO in patients with chronic liver disease were significantly decreased by 27% for those with hepatoma and 52% for those with hepatoma and cirrhosis. Serum DMO/TMO ratios at 4 h correlated well with liver function characteristics (total protein r=0.741, plasma albumin r=0.826, total bilirubin r=-0.725, cholinesterase r=0.853) as well as with pharmacokinetic parameters (total body clearance r=0.852, half-life r=-0.636) in both patients with normal livers and patients with chronic liver disease. This study suggests that serum DMO/TMO ratios in a blood sample obtained by a single collection after an oral administration of TMO might provide a clinically useful index of the hepatic drug-oxidizing capacity in an individual patient with chronic liver disease without determining the liver function characteristics or the pharmacokinetic parameters." @default.
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- W2022335967 date "1987-01-01" @default.
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- W2022335967 title "Trimethadione metabolism in patients with normal liver and in patients with chronic liver disease." @default.
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- W2022335967 doi "https://doi.org/10.1248/bpb1978.10.499" @default.
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