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- W2022338670 abstract "We have isolated a novel cDNA homologous to the family of nuclear hormone receptors which we have designated hippocampal zinc finger-2α (HZF-2α). HZF-2α encodes a protein 494 amino acids in length and predicted molecular size of 56 kD. HZF-2α shares sequence similarities with orphan nuclear receptors related to thyroid hormone and retinoic acid receptors. An additional HZF-2 cDNA clone, HZF-2β, was isolated. HZF-2β differs from HZF-2α in a nine-amino-acid region carboxyl to the DNA-binding domain thought to participate in enhancing the interaction of nuclear receptors with DNA. Northern blot analysis with a probe homologous to both HZF-2α and β identified two transcripts, sizes 4.4 and 5.5 kb in several rat tissues. HZF-2α/β mRNA levels are low in embryonic rat brain, increase during neonatal brain development and remain elevated in the adult rat brain. In situ hybridization analyses localized HZF-2α/β mRNA expression to all hippocampal subfields. Within the hippocampus heaviest expression was observed within the dentate gyrus. High levels of HZF-2α/β mRNA were also detected in Purkinje cells and the granular cell layer of the cerebellum. In summary, HZF-2α/β are novel orphan nuclear receptors which may play an important role in hormone-dependent aspects of developmental processes modulating hippocampal and cerebellar plasticity. © 1997 John Wiley & Sons, Inc. J Neurobiol 32: 341–358, 1997" @default.
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- W2022338670 date "1997-03-01" @default.
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- W2022338670 title "Molecular cloning and brain localization of HZF-2?, a new member of the Rev-erb subfamily of orphan nuclear receptors" @default.
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- W2022338670 doi "https://doi.org/10.1002/(sici)1097-4695(199703)32:3<341::aid-neu7>3.0.co;2-7" @default.
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