FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022338718> ?p ?o ?g. }

• W2022338718 endingPage "748" @default.
• W2022338718 startingPage "740" @default.
• W2022338718 abstract "Summary In recent years microarrays have been used extensively to characterize gene expression in acute lymphoblastic leukaemia (ALL). Few studies, however, have analysed normal haematopoietic cell populations to identify altered gene expression in ALL. We used oligonucleotide microarrays to compare the gene expression profile of paediatric precursor‐B (pre‐B) ALL specimens with two control cell populations, normal CD34 + and CD19 + IgM − cells, to focus on genes linked to leukemogenesis. A set of eight genes was identified with a ninefold higher average expression in ALL specimens compared with control cells. All of these genes were significantly deregulated in an independent cohort of 101 ALL specimens. One gene, connective tissue growth factor ( CTGF , also known as CCN2 ), had exceptionally high expression, which was confirmed in three independent leukaemia studies. Further analysis of CTGF expression in ALL revealed exclusive expression in B‐lineage, not T‐lineage, ALL. Within B‐lineage ALL approximately 75% of specimens were consistently positive for CTGF expression, however, specimens containing the E2A‐PBX1 translocation showed low or no expression. Protein studies using Western blot analysis demonstrated the presence of CTGF in ALL cell‐conditioned media. These findings indicate that CTGF is secreted by pre‐B ALL cells and may play a role in the pathophysiology of this disease." @default.
• W2022338718 created "2016-06-24" @default.
• W2022338718 creator A5002306566 @default.
• W2022338718 creator A5014275071 @default.
• W2022338718 creator A5028993050 @default.
• W2022338718 creator A5031144206 @default.
• W2022338718 creator A5031588652 @default.
• W2022338718 creator A5064712852 @default.
• W2022338718 creator A5075722318 @default.
• W2022338718 creator A5083186525 @default.
• W2022338718 date "2007-08-23" @default.
• W2022338718 modified "2023-10-16" @default.
• W2022338718 title "High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia" @default.
• W2022338718 cites W1517503216 @default.
• W2022338718 cites W1529003705 @default.
• W2022338718 cites W1583052686 @default.
• W2022338718 cites W1967236086 @default.
• W2022338718 cites W1971318940 @default.
• W2022338718 cites W1979076069 @default.
• W2022338718 cites W1980394634 @default.
• W2022338718 cites W1996293220 @default.
• W2022338718 cites W1999843107 @default.
• W2022338718 cites W2005463323 @default.
• W2022338718 cites W2014185712 @default.
• W2022338718 cites W2014326933 @default.
• W2022338718 cites W2015196791 @default.
• W2022338718 cites W2016833582 @default.
• W2022338718 cites W2021962516 @default.
• W2022338718 cites W2033681375 @default.
• W2022338718 cites W2033941781 @default.
• W2022338718 cites W2034269086 @default.
• W2022338718 cites W2056658806 @default.
• W2022338718 cites W2057613131 @default.
• W2022338718 cites W2061165036 @default.
• W2022338718 cites W2064757398 @default.
• W2022338718 cites W2067182377 @default.
• W2022338718 cites W2070579301 @default.
• W2022338718 cites W2078840238 @default.
• W2022338718 cites W2093426224 @default.
• W2022338718 cites W2100737258 @default.
• W2022338718 cites W2105685348 @default.
• W2022338718 cites W2109972881 @default.
• W2022338718 cites W2111090537 @default.
• W2022338718 cites W2111630252 @default.
• W2022338718 cites W2112509049 @default.
• W2022338718 cites W2114017617 @default.
• W2022338718 cites W2114752142 @default.
• W2022338718 cites W2120400575 @default.
• W2022338718 cites W2122742138 @default.
• W2022338718 cites W2136418557 @default.
• W2022338718 cites W2149052195 @default.
• W2022338718 cites W2150075535 @default.
• W2022338718 cites W2154174652 @default.
• W2022338718 cites W2161930777 @default.
• W2022338718 cites W2162424291 @default.
• W2022338718 cites W2165207521 @default.
• W2022338718 cites W2169808956 @default.
• W2022338718 cites W2170963456 @default.
• W2022338718 cites W2170989872 @default.
• W2022338718 cites W4236983842 @default.
• W2022338718 cites W4246697467 @default.
• W2022338718 doi "https://doi.org/10.1111/j.1365-2141.2007.06739.x" @default.
• W2022338718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17760805" @default.
• W2022338718 hasPublicationYear "2007" @default.
• W2022338718 type Work @default.
• W2022338718 sameAs 2022338718 @default.
• W2022338718 citedByCount "32" @default.
• W2022338718 countsByYear W20223387182012 @default.
• W2022338718 countsByYear W20223387182013 @default.
• W2022338718 countsByYear W20223387182014 @default.
• W2022338718 countsByYear W20223387182015 @default.
• W2022338718 countsByYear W20223387182016 @default.
• W2022338718 countsByYear W20223387182017 @default.
• W2022338718 countsByYear W20223387182019 @default.
• W2022338718 countsByYear W20223387182020 @default.
• W2022338718 countsByYear W20223387182021 @default.
• W2022338718 countsByYear W20223387182022 @default.
• W2022338718 countsByYear W20223387182023 @default.
• W2022338718 crossrefType "journal-article" @default.
• W2022338718 hasAuthorship W2022338718A5002306566 @default.
• W2022338718 hasAuthorship W2022338718A5014275071 @default.
• W2022338718 hasAuthorship W2022338718A5028993050 @default.
• W2022338718 hasAuthorship W2022338718A5031144206 @default.
• W2022338718 hasAuthorship W2022338718A5031588652 @default.
• W2022338718 hasAuthorship W2022338718A5064712852 @default.
• W2022338718 hasAuthorship W2022338718A5075722318 @default.
• W2022338718 hasAuthorship W2022338718A5083186525 @default.
• W2022338718 hasBestOaLocation W20223387181 @default.
• W2022338718 hasConcept C104317684 @default.
• W2022338718 hasConcept C109159458 @default.
• W2022338718 hasConcept C150194340 @default.
• W2022338718 hasConcept C153911025 @default.
• W2022338718 hasConcept C170493617 @default.
• W2022338718 hasConcept C180361614 @default.
• W2022338718 hasConcept C18431079 @default.
• W2022338718 hasConcept C203014093 @default.
• W2022338718 hasConcept C2775960820 @default.
• W2022338718 hasConcept C2778957590 @default.

• next