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• W2022339063 endingPage "1645" @default.
• W2022339063 startingPage "1643" @default.
• W2022339063 abstract "Ebola virus (EboV) causes rapidly fatal hemorrhagic fever in humans and there is currently no effective treatment. We found that the infection of African green monkey kidney (Vero) cells by vesicular stomatitis viruses bearing the EboV glycoprotein (GP) requires the activity of endosomal cysteine proteases. Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry. Biochemical studies demonstrate that CatB and CatL mediate entry by carrying out proteolysis of the EboV GP subunit GP1 and support a multistep mechanism that explains the relative contributions of these enzymes to infection. CatB and CatB/CatL inhibitors diminish the multiplication of infectious EboV-Zaire in cultured cells and may merit investigation as anti-EboV drugs." @default.
• W2022339063 created "2016-06-24" @default.
• W2022339063 creator A5010190528 @default.
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• W2022339063 date "2005-06-10" @default.
• W2022339063 modified "2023-10-18" @default.
• W2022339063 title "Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection" @default.
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• W2022339063 doi "https://doi.org/10.1126/science.1110656" @default.
• W2022339063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4797943" @default.
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