Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022339065> ?p ?o ?g. }
- W2022339065 endingPage "158" @default.
- W2022339065 startingPage "142" @default.
- W2022339065 abstract "Voltage-gated Na(+) channels are integral membrane proteins that function as a gateway for a selective permeation of sodium ions across biological membranes. In this way, they are crucial players for the generation of action potentials in excitable cells. Voltage-gated Na(+) channels are encoded by at least nine genes in mammals. The different isoforms have remarkably similar functional properties, but small changes in function and pharmacology are biologically well-defined, as underscored by mutations that cause several diseases and by modulation of a myriad of compounds, respectively. This review will stress on the modulation of voltage-gated Na(+) channels by scorpion alpha-toxins. Nature has designed these two classes of molecules as if they were predestined to each other: an inevitable 'encounter' between a voltage-gated Na(+) channel isoform and an alpha-toxin from scorpion venom indeed results in a dramatically changed Na(+) current phenotype with clear-cut consequences on electrical excitability and sometimes life or death. This fascinating aspect justifies an overview on scorpion venoms, their alpha-toxins and the Na(+) channel targets they are built for, as well as on the molecular determinants that govern the selectivity and affinity of this 'inseparable duo'." @default.
- W2022339065 created "2016-06-24" @default.
- W2022339065 creator A5021345022 @default.
- W2022339065 creator A5027586688 @default.
- W2022339065 date "2007-02-01" @default.
- W2022339065 modified "2023-10-17" @default.
- W2022339065 title "Voltage-gated sodium channel modulation by scorpion α-toxins" @default.
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