FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022341306> ?p ?o ?g. }

• W2022341306 endingPage "2447" @default.
• W2022341306 startingPage "2441" @default.
• W2022341306 abstract "N-carbamoylation is the non-enzymatic reaction of cyanate with amino groups. Due to urea-formed cyanate in uremic patients beside carbamoylated proteins also free amino acid carbamoylation has been detected, a modification which has been linked to disturbed protein synthesis as NH2-derivatisation interferes with peptide bond formation. HOCl the product of the activated MPO/H2O2/Cl− system is known to react with the NH2-group of free amino acids to form chloramines which could exert some protective effect against protein modification and cytotoxicity induced by HOCl. As N-carbamoylation may inhibit formation of chloramines we have used N-carbamoyl-threonine as a model amino acid to study its ability to limit the reactivity of HOCl with proteins (LDL and human serum albumin) and cells (THP-1 monocytes and coronary artery endothelial cells). The data indicate that N-carbamoylation completely abolished the protein- and cell-protective effect of threonine against HOCl attack. In contrast to threonine the reaction of HOCl with carbamoyl-threonine resulted in the formation of volatile oxidant species with protein modifying and cytotoxic potential. The volatile lipophilic inorganic monochloramine (NH2Cl) was identified as a breakdown product of this reaction." @default.
• W2022341306 created "2016-06-24" @default.
• W2022341306 creator A5010292536 @default.
• W2022341306 creator A5029196374 @default.
• W2022341306 creator A5029564948 @default.
• W2022341306 creator A5046156507 @default.
• W2022341306 creator A5050821605 @default.
• W2022341306 creator A5066376515 @default.
• W2022341306 creator A5068870510 @default.
• W2022341306 creator A5090532740 @default.
• W2022341306 date "2012-11-01" @default.
• W2022341306 modified "2023-10-17" @default.
• W2022341306 title "Carbamoylated free amino acids in uremia: HOCl generates volatile protein modifying and cytotoxic oxidant species from N-carbamoyl-threonine but not threonine" @default.
• W2022341306 cites W1500574791 @default.
• W2022341306 cites W1511580398 @default.
• W2022341306 cites W1515001810 @default.
• W2022341306 cites W1973187076 @default.
• W2022341306 cites W1981583167 @default.
• W2022341306 cites W1986089744 @default.
• W2022341306 cites W1996859289 @default.
• W2022341306 cites W1997613860 @default.
• W2022341306 cites W1998387376 @default.
• W2022341306 cites W1998989384 @default.
• W2022341306 cites W2004163374 @default.
• W2022341306 cites W2004965454 @default.
• W2022341306 cites W2006262620 @default.
• W2022341306 cites W2009086913 @default.
• W2022341306 cites W2009540635 @default.
• W2022341306 cites W2015591510 @default.
• W2022341306 cites W2016710662 @default.
• W2022341306 cites W2024630584 @default.
• W2022341306 cites W2028031080 @default.
• W2022341306 cites W2046952531 @default.
• W2022341306 cites W2052562838 @default.
• W2022341306 cites W2055787048 @default.
• W2022341306 cites W2061679481 @default.
• W2022341306 cites W2064032547 @default.
• W2022341306 cites W2073217256 @default.
• W2022341306 cites W2073363749 @default.
• W2022341306 cites W2075480784 @default.
• W2022341306 cites W2075671232 @default.
• W2022341306 cites W2076846032 @default.
• W2022341306 cites W2077976709 @default.
• W2022341306 cites W2078031981 @default.
• W2022341306 cites W2080937909 @default.
• W2022341306 cites W2086452478 @default.
• W2022341306 cites W2086979806 @default.
• W2022341306 cites W2088424323 @default.
• W2022341306 cites W2101959755 @default.
• W2022341306 cites W2118480498 @default.
• W2022341306 cites W2142341444 @default.
• W2022341306 cites W2146408273 @default.
• W2022341306 cites W2163577764 @default.
• W2022341306 cites W2212323528 @default.
• W2022341306 cites W2474298596 @default.
• W2022341306 cites W4239207916 @default.
• W2022341306 cites W4244571928 @default.
• W2022341306 cites W4249196138 @default.
• W2022341306 cites W989016558 @default.
• W2022341306 doi "https://doi.org/10.1016/j.biochi.2012.06.032" @default.
• W2022341306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22776434" @default.
• W2022341306 hasPublicationYear "2012" @default.
• W2022341306 type Work @default.
• W2022341306 sameAs 2022341306 @default.
• W2022341306 citedByCount "7" @default.
• W2022341306 countsByYear W20223413062013 @default.
• W2022341306 countsByYear W20223413062014 @default.
• W2022341306 countsByYear W20223413062015 @default.
• W2022341306 countsByYear W20223413062016 @default.
• W2022341306 countsByYear W20223413062022 @default.
• W2022341306 crossrefType "journal-article" @default.
• W2022341306 hasAuthorship W2022341306A5010292536 @default.
• W2022341306 hasAuthorship W2022341306A5029196374 @default.
• W2022341306 hasAuthorship W2022341306A5029564948 @default.
• W2022341306 hasAuthorship W2022341306A5046156507 @default.
• W2022341306 hasAuthorship W2022341306A5050821605 @default.
• W2022341306 hasAuthorship W2022341306A5066376515 @default.
• W2022341306 hasAuthorship W2022341306A5068870510 @default.
• W2022341306 hasAuthorship W2022341306A5090532740 @default.
• W2022341306 hasConcept C178790620 @default.
• W2022341306 hasConcept C181199279 @default.
• W2022341306 hasConcept C185592680 @default.
• W2022341306 hasConcept C2775880066 @default.
• W2022341306 hasConcept C2776414213 @default.
• W2022341306 hasConcept C2779195922 @default.
• W2022341306 hasConcept C2779281246 @default.
• W2022341306 hasConcept C2779488458 @default.
• W2022341306 hasConcept C2780908991 @default.
• W2022341306 hasConcept C505241676 @default.
• W2022341306 hasConcept C515207424 @default.
• W2022341306 hasConcept C55493867 @default.
• W2022341306 hasConceptScore W2022341306C178790620 @default.
• W2022341306 hasConceptScore W2022341306C181199279 @default.
• W2022341306 hasConceptScore W2022341306C185592680 @default.
• W2022341306 hasConceptScore W2022341306C2775880066 @default.
• W2022341306 hasConceptScore W2022341306C2776414213 @default.
• W2022341306 hasConceptScore W2022341306C2779195922 @default.
• W2022341306 hasConceptScore W2022341306C2779281246 @default.

• next