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- W2022341655 abstract "PROBENECID (Benemid) * resulted from a prolonged research effort directed toward the discovery of a safe agent that, administered orally, would physiologically inhibit the renal tubular secretion of penicillin.<sup>1</sup>Introduced into clinical medicine on July 22, 1949,<sup>2</sup>the use for which it was intended has increased steadily, and new indications for the drug have been disclosed. A conservative estimate indicates that 4,000,000 patient days (15,626 patient years) of therapy have been administered. Granting that the record of side-effects following the use of any therapeutic agent is not static, and that continuing use will bring to light an increasing number of side-effects and toxic manifestations, an appraisal from time to time seems appropriate. A preliminary assessment of the toxicity of probenecid was presented in 1951 on the basis of 701 patients,<sup>49</sup>and it is now possible to report on 2,502 patients. The information reported here has been derived from" @default.
- W2022341655 created "2016-06-24" @default.
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- W2022341655 date "1955-01-01" @default.
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- W2022341655 title "PROBENECID (BENEMID)" @default.
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- W2022341655 doi "https://doi.org/10.1001/archinte.1955.00250070099012" @default.
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