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• W2022341831 endingPage "275" @default.
• W2022341831 startingPage "266" @default.
• W2022341831 abstract "We investigated on the role of the genes encoding for the ATP-sensitive K+-channel (KATP) subunits (SUR1-2A/B, Kir6.2) in the atrophy induced “in vitro” by staurosporine (STS) in different skeletal muscle phenotypes of mouse. Patch-clamp and gene expression experiments showed that the expression/activity of the sarcolemma KATP channel subunits was higher in the fast-twitch than in the slow-twitch fibers. After 1 to 3 h of incubation time, the STS (2.14 × 10−6 M) treatment enhanced the expression/activity of the SUR2B, SUR1 and Kir6.2 subunit genes, but not SUR2A, in the slow-twitch muscle fibers, induced the caspase-3-9, Atrogin-1 and Murf-1 gene expression without affecting protein content. After 3 to 6 h, the STS-related atrophy markedly down-regulated the SUR2B, SUR1 and Kir6.2 genes reducing the KATP currents and reduced the protein content/muscle weight ratio of the slow-twitch muscle by −36.4 ± 6% (p < 0.05). After 6 to 24 h, no additional changes of the SUR1-2B and Kir6.2 gene expression and muscle protein were observed. In the fast-twitch muscles, STS mildly affected the atrophic genes and protein content, but potentiated the KATP currents down-regulating the Bnip-3 gene. Diazoxide (250–500 × 10−6 M), a SUR1-2B/Kir6.2 channel opener, prevented the protein loss induced by STS in the slow-twitch muscle after 6 h showing an EC50 of 1.35 × 10−7 M and Emax of 75%, down-regulated the caspase-9 gene and enhanced the KATP currents. The enhanced expression/activity of the SUR2B, SUR1 and Kir6.2 genes are cytoprotective against STS-induced atrophy in the slow-twitch muscle; their reduced expression/activity is associated with proteolysis and atrophy in skeletal muscle." @default.
• W2022341831 created "2016-06-24" @default.
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• W2022341831 date "2014-09-01" @default.
• W2022341831 modified "2023-09-27" @default.
• W2022341831 title "Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes" @default.
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• W2022341831 doi "https://doi.org/10.1016/j.bcp.2014.06.023" @default.
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