Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022345520> ?p ?o ?g. }
- W2022345520 endingPage "204" @default.
- W2022345520 startingPage "196" @default.
- W2022345520 abstract "Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and rhein (4,5-dihydroxyanthraquinone-2-carboxyl acid) are two main active compounds in total rhubarb anthraquinones (TRAs), which showed nephrotoxicity in Sprague Dawley (S.D.) rats in our previous study. However, it is unknown yet whether emodin and rhein have cytotoxic effects on kidney. To address this issue, HK-2 cells, a human proximal tubular epithelial cell line, were treated with different concentrations of emodin or rhein, and cell viability and morphological changes were investigated. The ratio of hypodiploid cells and the activity of caspase 3 protease were also detected. Results showed that addition of emodin but not rhein at concentrations above 40 μM for 24 h reduced cell viability and induced apoptosis in HK-2 cells. Additionally, emodin at apoptosis-inducing concentrations caused expression of cathepsin B (CB) protein and activation of CB protease. Addition of CB inhibitor, CA-074, significantly attenuated the ratio of hypodiploid and apoptotic cells, partially blocked caspase 3 activation and inhibited reduction of cell viability induced by emodin. These data indicate that emodin possesses cytotoxic effects on HK-2 cells partially through induction of CB protein and activation of CB protease." @default.
- W2022345520 created "2016-06-24" @default.
- W2022345520 creator A5002705826 @default.
- W2022345520 creator A5003128598 @default.
- W2022345520 creator A5008090064 @default.
- W2022345520 creator A5013818650 @default.
- W2022345520 creator A5028072681 @default.
- W2022345520 creator A5041530586 @default.
- W2022345520 creator A5041748603 @default.
- W2022345520 creator A5058165407 @default.
- W2022345520 creator A5058555021 @default.
- W2022345520 creator A5079618691 @default.
- W2022345520 creator A5081021942 @default.
- W2022345520 date "2008-10-01" @default.
- W2022345520 modified "2023-09-25" @default.
- W2022345520 title "Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells" @default.
- W2022345520 cites W1492587973 @default.
- W2022345520 cites W1547781918 @default.
- W2022345520 cites W1964198812 @default.
- W2022345520 cites W1977219317 @default.
- W2022345520 cites W1989458137 @default.
- W2022345520 cites W1992012112 @default.
- W2022345520 cites W2003601985 @default.
- W2022345520 cites W2005316029 @default.
- W2022345520 cites W2018949373 @default.
- W2022345520 cites W2019631673 @default.
- W2022345520 cites W2027339280 @default.
- W2022345520 cites W2030400542 @default.
- W2022345520 cites W2036339952 @default.
- W2022345520 cites W2044736808 @default.
- W2022345520 cites W2045315429 @default.
- W2022345520 cites W2045336785 @default.
- W2022345520 cites W2054253197 @default.
- W2022345520 cites W2060137381 @default.
- W2022345520 cites W2062413384 @default.
- W2022345520 cites W2062832507 @default.
- W2022345520 cites W2084609653 @default.
- W2022345520 cites W2085482737 @default.
- W2022345520 cites W2085908398 @default.
- W2022345520 cites W2088191210 @default.
- W2022345520 cites W2091998314 @default.
- W2022345520 cites W2100495176 @default.
- W2022345520 cites W2114487246 @default.
- W2022345520 cites W2127052230 @default.
- W2022345520 cites W2134388096 @default.
- W2022345520 cites W2135233980 @default.
- W2022345520 cites W2142120946 @default.
- W2022345520 cites W2182856794 @default.
- W2022345520 cites W2318627331 @default.
- W2022345520 doi "https://doi.org/10.1016/j.toxlet.2008.05.013" @default.
- W2022345520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18789614" @default.
- W2022345520 hasPublicationYear "2008" @default.
- W2022345520 type Work @default.
- W2022345520 sameAs 2022345520 @default.
- W2022345520 citedByCount "31" @default.
- W2022345520 countsByYear W20223455202012 @default.
- W2022345520 countsByYear W20223455202013 @default.
- W2022345520 countsByYear W20223455202014 @default.
- W2022345520 countsByYear W20223455202015 @default.
- W2022345520 countsByYear W20223455202016 @default.
- W2022345520 countsByYear W20223455202017 @default.
- W2022345520 countsByYear W20223455202018 @default.
- W2022345520 countsByYear W20223455202019 @default.
- W2022345520 countsByYear W20223455202020 @default.
- W2022345520 countsByYear W20223455202021 @default.
- W2022345520 countsByYear W20223455202022 @default.
- W2022345520 countsByYear W20223455202023 @default.
- W2022345520 crossrefType "journal-article" @default.
- W2022345520 hasAuthorship W2022345520A5002705826 @default.
- W2022345520 hasAuthorship W2022345520A5003128598 @default.
- W2022345520 hasAuthorship W2022345520A5008090064 @default.
- W2022345520 hasAuthorship W2022345520A5013818650 @default.
- W2022345520 hasAuthorship W2022345520A5028072681 @default.
- W2022345520 hasAuthorship W2022345520A5041530586 @default.
- W2022345520 hasAuthorship W2022345520A5041748603 @default.
- W2022345520 hasAuthorship W2022345520A5058165407 @default.
- W2022345520 hasAuthorship W2022345520A5058555021 @default.
- W2022345520 hasAuthorship W2022345520A5079618691 @default.
- W2022345520 hasAuthorship W2022345520A5081021942 @default.
- W2022345520 hasConcept C12519072 @default.
- W2022345520 hasConcept C153911025 @default.
- W2022345520 hasConcept C154317977 @default.
- W2022345520 hasConcept C167844969 @default.
- W2022345520 hasConcept C181199279 @default.
- W2022345520 hasConcept C185592680 @default.
- W2022345520 hasConcept C190283241 @default.
- W2022345520 hasConcept C202751555 @default.
- W2022345520 hasConcept C2776714187 @default.
- W2022345520 hasConcept C2778248515 @default.
- W2022345520 hasConcept C2780867653 @default.
- W2022345520 hasConcept C28021979 @default.
- W2022345520 hasConcept C31573885 @default.
- W2022345520 hasConcept C53227056 @default.
- W2022345520 hasConcept C54355233 @default.
- W2022345520 hasConcept C55493867 @default.
- W2022345520 hasConcept C56928146 @default.
- W2022345520 hasConcept C59822182 @default.
- W2022345520 hasConcept C81885089 @default.