Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022346538> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2022346538 endingPage "453" @default.
- W2022346538 startingPage "445" @default.
- W2022346538 abstract "Large proximal and smaller distal coronary arteries respond differently to pharmacologic agents, but the role of autoregulation is not known. We examined this role in dogs by cannulating the main left coronary artery and a distal left anterior descending artery branch. With coronary flow held constant, the distal coronary artery pressure and the gradient from proximal to distal artery were proportional to the small and the large vessel resistance, respectively. At normal perfusion pressure, nitroglycerin injected directly into the coronary artery caused a transient fall in small vessel resistance and a prolonged decrease in large vessel resistance. During ischemia, when small vessels autoregulated and small vessel resistance was minimal, nitroglycerin lowered only large vessel resistance. Angiotensin injected directly into the coronary artery increased small and large vessel resistance; the slower response of large vessel resistance followed a passive dilation caused by increased perfusion pressure. Continuous infusions of nitroglycerin and angiotensin maintained dilation and constriction of large vessels, respectively, but small vessels demonstrated tachyphylaxis. Only adenosine infusion maintained dilation in both large and small vessels. In response to varying perfusion, small vessels autoregulated and large vessels responded passively to changes in perfusion pressure. We concluded that small coronary arteries respond to cardiac metabolism and demonstrate escape from prolonged dilation and constriction. Conversely, large vessels respond continuously to sustained mechanical and pharmacologic stimuli independently of the nutritional state of the myocardium." @default.
- W2022346538 created "2016-06-24" @default.
- W2022346538 creator A5023127517 @default.
- W2022346538 creator A5070278686 @default.
- W2022346538 date "1973-10-01" @default.
- W2022346538 modified "2023-09-30" @default.
- W2022346538 title "Differential Response of Large and Small Coronary Arteries to Nitroglycerin and Angiotensin" @default.
- W2022346538 cites W1965632978 @default.
- W2022346538 cites W2008006948 @default.
- W2022346538 cites W2022673204 @default.
- W2022346538 cites W2038204666 @default.
- W2022346538 cites W2094844410 @default.
- W2022346538 cites W2121163521 @default.
- W2022346538 cites W2130202416 @default.
- W2022346538 cites W2141851415 @default.
- W2022346538 cites W2163858305 @default.
- W2022346538 cites W2410851250 @default.
- W2022346538 cites W2413027950 @default.
- W2022346538 doi "https://doi.org/10.1161/01.res.33.4.445" @default.
- W2022346538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4355038" @default.
- W2022346538 hasPublicationYear "1973" @default.
- W2022346538 type Work @default.
- W2022346538 sameAs 2022346538 @default.
- W2022346538 citedByCount "127" @default.
- W2022346538 countsByYear W20223465382012 @default.
- W2022346538 countsByYear W20223465382014 @default.
- W2022346538 countsByYear W20223465382015 @default.
- W2022346538 countsByYear W20223465382016 @default.
- W2022346538 countsByYear W20223465382018 @default.
- W2022346538 countsByYear W20223465382020 @default.
- W2022346538 crossrefType "journal-article" @default.
- W2022346538 hasAuthorship W2022346538A5023127517 @default.
- W2022346538 hasAuthorship W2022346538A5070278686 @default.
- W2022346538 hasBestOaLocation W20223465381 @default.
- W2022346538 hasConcept C120770815 @default.
- W2022346538 hasConcept C126322002 @default.
- W2022346538 hasConcept C146957229 @default.
- W2022346538 hasConcept C164705383 @default.
- W2022346538 hasConcept C174940676 @default.
- W2022346538 hasConcept C178853913 @default.
- W2022346538 hasConcept C2776820930 @default.
- W2022346538 hasConcept C2778742706 @default.
- W2022346538 hasConcept C2780231137 @default.
- W2022346538 hasConcept C2908929049 @default.
- W2022346538 hasConcept C2994477613 @default.
- W2022346538 hasConcept C541997718 @default.
- W2022346538 hasConcept C58245268 @default.
- W2022346538 hasConcept C71924100 @default.
- W2022346538 hasConcept C72859922 @default.
- W2022346538 hasConcept C84393581 @default.
- W2022346538 hasConceptScore W2022346538C120770815 @default.
- W2022346538 hasConceptScore W2022346538C126322002 @default.
- W2022346538 hasConceptScore W2022346538C146957229 @default.
- W2022346538 hasConceptScore W2022346538C164705383 @default.
- W2022346538 hasConceptScore W2022346538C174940676 @default.
- W2022346538 hasConceptScore W2022346538C178853913 @default.
- W2022346538 hasConceptScore W2022346538C2776820930 @default.
- W2022346538 hasConceptScore W2022346538C2778742706 @default.
- W2022346538 hasConceptScore W2022346538C2780231137 @default.
- W2022346538 hasConceptScore W2022346538C2908929049 @default.
- W2022346538 hasConceptScore W2022346538C2994477613 @default.
- W2022346538 hasConceptScore W2022346538C541997718 @default.
- W2022346538 hasConceptScore W2022346538C58245268 @default.
- W2022346538 hasConceptScore W2022346538C71924100 @default.
- W2022346538 hasConceptScore W2022346538C72859922 @default.
- W2022346538 hasConceptScore W2022346538C84393581 @default.
- W2022346538 hasIssue "4" @default.
- W2022346538 hasLocation W20223465381 @default.
- W2022346538 hasLocation W20223465382 @default.
- W2022346538 hasOpenAccess W2022346538 @default.
- W2022346538 hasPrimaryLocation W20223465381 @default.
- W2022346538 hasRelatedWork W165510812 @default.
- W2022346538 hasRelatedWork W2008016552 @default.
- W2022346538 hasRelatedWork W2012383867 @default.
- W2022346538 hasRelatedWork W2035040324 @default.
- W2022346538 hasRelatedWork W2055450287 @default.
- W2022346538 hasRelatedWork W2071712662 @default.
- W2022346538 hasRelatedWork W2081869822 @default.
- W2022346538 hasRelatedWork W2162291076 @default.
- W2022346538 hasRelatedWork W2411372493 @default.
- W2022346538 hasRelatedWork W2907724389 @default.
- W2022346538 hasVolume "33" @default.
- W2022346538 isParatext "false" @default.
- W2022346538 isRetracted "false" @default.
- W2022346538 magId "2022346538" @default.
- W2022346538 workType "article" @default.