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- W2022348540 abstract "skin, gastrointestinal and genitourinary tracts, cardiac, smooth and skeletal muscle and immune cells (lymphocytes, mast cells and eosinophils). Dysregulation of NGF expression and signalling have been described in allergy, asthma, inflammation in the gut, chronic constipation, coronary artery disease and some cancers. In prostate cancer NGF stimulates tumour cell growth and metastasis and may drive nerve sprouting and infiltration. Inhibiting NGF by using blocking antibodies has a significant analgesic effect and is proposed to decrease metastatic cancer pain. Aim: ProNGF expression has not been previously described in tumours of the gastrointestinal tract. Materials and Methods: The expression of proNGF was examined by immunocytochemistry of esophageal squamous cancer (SCC) (15 cases), gastric adenocarcinoma (10 cases) and colorectal adenocarcinoma (12 cases) and corresponding normal adjacent tissues in the gut in tumour microarrays (Figure 1). Sections were scored for site of cytoplasmic staining in esophagus and cancer grade. Results: All gut epithelial tissue expressed pro-NGF. In normal oesophageal squamous epithelium expression site was diffuse, superficial or basal (Figure 2), in squamous carcinoma, staining was intense and diffuse. In adenocarcinomas (stomach and colon) staining was diffuse, and in intestinal metaplasia (IM) in the stomach, staining was more intense compared to adjacent gastric epithelium. There was no significant difference in intensity of staining by grade of cancer. Conclusions: There is significant expression of pro-NGF in squamous oesophageal and gastrointestinal columnar epithelium in both normal tissue and cancer. Pro-NGF may be therefore be a target of interest in biomarker exploration and therapeutic development for inhibition of cancer growth and cancer pain." @default.
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- W2022348540 date "2014-05-01" @default.
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- W2022348540 title "Sa1941 The Candidate Molecular Markers for Evaluating the Risk of Gastric Cancer After Helicobacter pylori Eradication" @default.
- W2022348540 doi "https://doi.org/10.1016/s0016-5085(14)61210-5" @default.
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