Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022351987> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2022351987 endingPage "e216" @default.
- W2022351987 startingPage "e214" @default.
- W2022351987 abstract "To the Editor: A 37-year-old African American woman was admitted to the hospital with weakness and pain in her abdomen and thighs. Her medical history was significant for severe eclampsia and multiple thrombotic events, which resulted in end-stage renal disease and a diagnosis of antiphospholipid syndrome (APS). The diagnosis of APS was confirmed with positive serology on two occasions separated by several months, and led to the initiation of lifelong anticoagulation therapy with warfarin. The patient was known to be noncompliant with anticoagulation, but had a therapeutic international normalized ratio at the time of her hospital admission. Within 1 week during hospitalization, the patient developed livedo reticularis (Fig 1, A) and hemorrhagic bullae on her thighs (Fig 1, B) and breast with severe hypotension, encephalopathy, respiratory failure, and thrombocytopenia. Multiple antibiotics were implemented for a presumptive diagnosis of sepsis, however all cultures were negative. A medium vessel vasculitis and calciphylaxis were considered, however punch biopsy specimens of skin lesions showed an extensive thrombogenic vasculopathy (Fig 1, C) with no inflammatory infiltrate or calcium deposition. Multiple causes with consistent histopathologic findings were considered, including warfarin-induced skin necrosis, heparin-induced thrombocytopenia and thrombosis, purpura fulminans, APS, type I cryoglobulinemia, cryofibrinogenemia, and various hereditary thrombophilic disorders, prompting a full hypercoagulability workup. Antiplatelet factor 4, cryoglobulin, cryofibrinogen, factor V Leiden, protein S, and the antiphospholipid antibodies were all within normal limits. Despite negative laboratory findings, a presumptive diagnosis of catastrophic APS (CAPS) was made and intravenous immunoglobulin, plasmapheresis, corticosteroids, and aggressive anticoagulation with intravenous heparin were started. Repeated laboratory tests revealed an elevated lupus anticoagulant and anti-beta-2-glycoprotein IgA antibodies, supporting the diagnosis and treatment plan. Despite initial stabilization, the patient's condition declined and she subsequently died. Autopsy revealed pulmonary emboli, a splenic infarct, ischemic bowel secondary to diffuse thrombi, and no evidence of calciphylaxis. These findings, in addition to the positive antiphospholipid serologies, confirmed a definitive diagnosis of CAPS. This case has subsequently been reviewed and accepted into the international CAPS registry." @default.
- W2022351987 created "2016-06-24" @default.
- W2022351987 creator A5027863846 @default.
- W2022351987 creator A5034713129 @default.
- W2022351987 creator A5062199574 @default.
- W2022351987 creator A5071169412 @default.
- W2022351987 date "2012-11-01" @default.
- W2022351987 modified "2023-09-27" @default.
- W2022351987 title "Catastrophic antiphospholipid syndrome" @default.
- W2022351987 cites W1990336377 @default.
- W2022351987 cites W1998988407 @default.
- W2022351987 cites W2058863250 @default.
- W2022351987 cites W2119653886 @default.
- W2022351987 doi "https://doi.org/10.1016/j.jaad.2012.03.010" @default.
- W2022351987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23062920" @default.
- W2022351987 hasPublicationYear "2012" @default.
- W2022351987 type Work @default.
- W2022351987 sameAs 2022351987 @default.
- W2022351987 citedByCount "2" @default.
- W2022351987 countsByYear W20223519872019 @default.
- W2022351987 countsByYear W20223519872023 @default.
- W2022351987 crossrefType "journal-article" @default.
- W2022351987 hasAuthorship W2022351987A5027863846 @default.
- W2022351987 hasAuthorship W2022351987A5034713129 @default.
- W2022351987 hasAuthorship W2022351987A5062199574 @default.
- W2022351987 hasAuthorship W2022351987A5071169412 @default.
- W2022351987 hasConcept C126322002 @default.
- W2022351987 hasConcept C141071460 @default.
- W2022351987 hasConcept C159654299 @default.
- W2022351987 hasConcept C203014093 @default.
- W2022351987 hasConcept C2775934546 @default.
- W2022351987 hasConcept C2776015282 @default.
- W2022351987 hasConcept C2776301958 @default.
- W2022351987 hasConcept C2776874634 @default.
- W2022351987 hasConcept C2777247642 @default.
- W2022351987 hasConcept C2778842783 @default.
- W2022351987 hasConcept C2779134260 @default.
- W2022351987 hasConcept C2779161974 @default.
- W2022351987 hasConcept C2779974317 @default.
- W2022351987 hasConcept C2780022809 @default.
- W2022351987 hasConcept C2780439664 @default.
- W2022351987 hasConcept C2780868729 @default.
- W2022351987 hasConcept C71924100 @default.
- W2022351987 hasConcept C90924648 @default.
- W2022351987 hasConceptScore W2022351987C126322002 @default.
- W2022351987 hasConceptScore W2022351987C141071460 @default.
- W2022351987 hasConceptScore W2022351987C159654299 @default.
- W2022351987 hasConceptScore W2022351987C203014093 @default.
- W2022351987 hasConceptScore W2022351987C2775934546 @default.
- W2022351987 hasConceptScore W2022351987C2776015282 @default.
- W2022351987 hasConceptScore W2022351987C2776301958 @default.
- W2022351987 hasConceptScore W2022351987C2776874634 @default.
- W2022351987 hasConceptScore W2022351987C2777247642 @default.
- W2022351987 hasConceptScore W2022351987C2778842783 @default.
- W2022351987 hasConceptScore W2022351987C2779134260 @default.
- W2022351987 hasConceptScore W2022351987C2779161974 @default.
- W2022351987 hasConceptScore W2022351987C2779974317 @default.
- W2022351987 hasConceptScore W2022351987C2780022809 @default.
- W2022351987 hasConceptScore W2022351987C2780439664 @default.
- W2022351987 hasConceptScore W2022351987C2780868729 @default.
- W2022351987 hasConceptScore W2022351987C71924100 @default.
- W2022351987 hasConceptScore W2022351987C90924648 @default.
- W2022351987 hasIssue "5" @default.
- W2022351987 hasLocation W20223519871 @default.
- W2022351987 hasLocation W20223519872 @default.
- W2022351987 hasOpenAccess W2022351987 @default.
- W2022351987 hasPrimaryLocation W20223519871 @default.
- W2022351987 hasRelatedWork W1518349915 @default.
- W2022351987 hasRelatedWork W1671834425 @default.
- W2022351987 hasRelatedWork W1981080372 @default.
- W2022351987 hasRelatedWork W2013725827 @default.
- W2022351987 hasRelatedWork W2043893283 @default.
- W2022351987 hasRelatedWork W2093671368 @default.
- W2022351987 hasRelatedWork W2949411714 @default.
- W2022351987 hasRelatedWork W3013056934 @default.
- W2022351987 hasRelatedWork W3031428316 @default.
- W2022351987 hasRelatedWork W3146104950 @default.
- W2022351987 hasVolume "67" @default.
- W2022351987 isParatext "false" @default.
- W2022351987 isRetracted "false" @default.
- W2022351987 magId "2022351987" @default.
- W2022351987 workType "article" @default.