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- W2022352603 endingPage "e0119816" @default.
- W2022352603 startingPage "e0119816" @default.
- W2022352603 abstract "Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3–10% strain, 0.17–0.5 Hz, and 2–12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response." @default.
- W2022352603 created "2016-06-24" @default.
- W2022352603 creator A5048375463 @default.
- W2022352603 creator A5063917292 @default.
- W2022352603 creator A5072898291 @default.
- W2022352603 creator A5073892628 @default.
- W2022352603 date "2015-03-30" @default.
- W2022352603 modified "2023-10-17" @default.
- W2022352603 title "Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review" @default.
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