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- W2022352866 abstract "Neoplasms arising from the smooth muscle of the digestive tract are uncommon, comprising only 1% of GI tumors. 1 Diamond T Danton MH Parks TG. Smooth muscle tumors of the alimentary tract. Ann Royal Coll Surg Engl. 1990; 2: 316-320 Google Scholar These smooth muscle tumors are known for their variable clinical behavior and for the difficulty in determining whether they are benign or malignant. They have been classified traditionally as leiomyomas or leiomyosarcomas because they resemble smooth muscle tumors at other anatomic sites. However, their origin and differentiation have been a source of controversy. These tumors are thought to arise from primitive mesenchymal cells that show variable differentiation along one or more connective tissue cell lines. 2 Rosai J. Gastrointestinal tract. in: 8th ed. Ackerman’s surgical pathology. Mosby, St. Louis1996: 645-647 Google Scholar The term “gastrointestinal stromal tumor” (GIST) was devised for such neoplasms, acknowledging uncertainties in behavior and phenotype. 3 Franquemont D. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol. 1995; 103: 41-47 PubMed Google Scholar However, the large majority of these tumors exhibit differentiation toward smooth muscle cells, as evidenced by ultrastructural and immunohistochemic studies. 2 Rosai J. Gastrointestinal tract. in: 8th ed. Ackerman’s surgical pathology. Mosby, St. Louis1996: 645-647 Google Scholar" @default.
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- W2022352866 title "Multiple malignant gastric stromal tumors presenting with GI bleeding: a case report and a review of the literature" @default.
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- W2022352866 doi "https://doi.org/10.1016/s0016-5107(00)70427-5" @default.
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