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• W2022353277 abstract "As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoisomerases II and IV. We have investigated various subunits in this series and report advanced studies on compound 7 which demonstrates good PK and in vivo efficacy properties." @default.
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• W2022353277 date "2011-12-01" @default.
• W2022353277 modified "2023-09-23" @default.
• W2022353277 title "Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases" @default.
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• W2022353277 doi "https://doi.org/10.1016/j.bmcl.2011.09.114" @default.
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