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- W2022354108 abstract "Peripheral mononuclear cells from patients with autoimmune thyroiditis were evaluated using antigen-specific (human thyroglobulin (hTg)) and nonspecific (protein A) reverse hemolytic plaque-forming cell assays. Polyclonal stimulation (using pokeweed mitogen) of protein A-PFC was similar in patients and normal control subjects but hTg-PFC were only detected in patients with autoimmune thyroid disease. hTg itself was a nonspecific mitogen as judged by increases in protein A-PFC in both groups and similarly induced hTg-PFC in patients with autoimune thyroiditis. Both protein A-PFC and hTg-PFC were also induced in patients by coincubation with irradiated peripheral mononuclear cells but there was significantly less enhancement of the specific compared to the nonspecific plaque-forming cells. These data provided additional evidence to support the concept of a specific B-cell defect in autoimmune thyroid disease." @default.
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- W2022354108 title "Plaque-forming cells in autoimmune thyroid disease" @default.
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- W2022354108 doi "https://doi.org/10.1016/0090-1229(82)90069-1" @default.
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