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- W2022354573 abstract "The activity of purified bovine adrenocortical P-45011β on the C18-steroid, 4-estrene-3,17-dione (19-norandrostenedione), is described. The major steroid products were separated by HPLC and identified by GC-MS, and 1H- and 13C-NMR as 11β-, 18- and 6β-hydroxylated derivatives of 19-norandrostenedione. The turnover numbers of the 11β-, 18-and 6β-hydroxylase reactions were 45, 7.5 and 1.9 (mol/min/mol of P-45011β), respectively, with a common Km of 44 μM. All of these activities required the presence of the electron donating system consisting of NADPH, adrenal ferredoxin (adrenodoxin) and its reductase. These findings provide additional insights into the versatile catalytic roles of P-45011β in the adrenal cortex, in which it may act on C18-19-nor-steroids in addition to its known activities on C21 and C19-steroids." @default.
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- W2022354573 date "1990-07-01" @default.
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- W2022354573 title "Hydroxylation of 19-norandrostenedione by adrenal cortex mitochondrial P-45011β" @default.
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- W2022354573 doi "https://doi.org/10.1016/0022-4731(90)90230-p" @default.
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