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- W2022356161 abstract "The effects of an anxiolytic honokiol derivative, dihydrohonokiol-B (DHH-B) [3′-(2-propenyl)-5-propyl-(1,1′-biphenyl)-2,4′-diaol], on ammonia-induced increases in the intracellular Cl− concentration ([Cl−]i) were examined using primary cultured rat hippocampal neurons. DHH-B (1–100 ng/ml), but not an inactive isomer of honokiol, magnolol (100 ng/ml), dose-dependently inhibited the ammonia-induced increases in [Cl−]i without any changes in the control [Cl−]i. Such an effect of DHH-B was blocked by a gamma-aminobutylic acid A (GABAA) and GABAC Cl− channel blocker, 100 μM picrotoxin, and a GABAC receptor blocker, 10 μM (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, but not by a GABAA receptor blocker, 10 μM bicuculline. Further, a GABAC receptor agonist, 200 μM cis-4-aminocrotonic acid, but not a GABAA receptor agonist, 10 μM muscimol, mimicked the effect of DHH-B. Thus, DHH-B appears to protect neurons from the ammonia-induced increases in [Cl−]i through GABAC receptor stimulation." @default.
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- W2022356161 date "2001-10-01" @default.
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- W2022356161 title "An anxiolytic agent, dihydrohonokiol-B, inhibits ammonia-induced increases in the intracellular Cl− of cultured rat hippocampal neurons via GABAc receptors" @default.
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- W2022356161 doi "https://doi.org/10.1016/s0304-3940(01)02201-7" @default.
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