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- W2022356274 abstract "Different patterns of catecholamine release are produced by perfusion of isolated bovine adrenals with Cd2+, Ba2+, and Zn2+ (5 mm). The action of Zn2+ is weak but prolonged. The effect of Cd2+ is slow in onset and prolonged in duration compared to that of Ba2+. Neither Cd2+ nor Ba2+ increased release of the cytoplasmic enzyme, lactate dehydrogenase. These ions, therefore, do not disrupt adrenomedullary cells to cause catecholamine release. Neither Ba2+ nor Zn2+ affected 45Ca distribution in subcellular fractions of adrenal medulla. Cadmium ion, however, decreased mitochondrial and increased microsomal and supernatant 45Ca2+ contents. Mitochondria accumulated relatively large quantities of both cadmium and barium, but chromaffin granules contained twice as much cadmium as barium. Zinc contents were relatively low in all subcellular fractions. It is concluded that Cd2+ probably releases adrenal amines by mobilizing mitochondrial Ca and possibly by a direct effect on chromaffin granules. Barium ion does not affect the distribution of adrenomedullary cell Ca, but it probably mimics the action of Ca2+ in evoking catecholamine release. The weak effect of Zn2+ may be related to limited penetration of cells of adrenal medulla." @default.
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- W2022356274 title "Mechanisms of cadmium- and barium-induced adrenal catecholamine release" @default.
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- W2022356274 doi "https://doi.org/10.1016/0041-008x(78)90288-0" @default.
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