FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022356570> ?p ?o ?g. }

• W2022356570 endingPage "2275" @default.
• W2022356570 startingPage "2265" @default.
• W2022356570 abstract "Tyrosine kinase receptors of the EGFR family play a significant role in vital cellular processes and in various cancers. EGFR members are unique among kinases, as the regulatory elements of their kinase domains are constitutively ready for catalysis. Nevertheless, the receptors are not constantly active. This apparent paradox has prompted us to seek mechanisms of regulation in EGFR's cytoplasmic domain that do not involve conformational changes of the kinase domain. Our computational analyses, based on the three-dimensional structure of EGFR's kinase domain suggest that direct contact between the kinase and a segment from the C-terminal regulatory domains inhibits enzymatic activity. EGFR activation would then involve temporal dissociation of this stable complex, for example, via ligand-induced contact formation between the extracellular domains, leading to the reorientation of the transmembrane and intracellular domains. The model provides an explanation at the molecular level for the effects of several cancer-causing EGFR mutations." @default.
• W2022356570 created "2016-06-24" @default.
• W2022356570 creator A5024642832 @default.
• W2022356570 creator A5031768744 @default.
• W2022356570 creator A5037671858 @default.
• W2022356570 date "2004-12-01" @default.
• W2022356570 modified "2023-10-17" @default.
• W2022356570 title "A Putative Mechanism for Downregulation of the Catalytic Activity of the EGF Receptor via Direct Contact between Its Kinase and C-Terminal Domains" @default.
• W2022356570 cites W1482125983 @default.
• W2022356570 cites W1494731379 @default.
• W2022356570 cites W1497006347 @default.
• W2022356570 cites W1880089880 @default.
• W2022356570 cites W1964321121 @default.
• W2022356570 cites W1977957449 @default.
• W2022356570 cites W1985740734 @default.
• W2022356570 cites W1990222254 @default.
• W2022356570 cites W1991183597 @default.
• W2022356570 cites W1992945955 @default.
• W2022356570 cites W2006911242 @default.
• W2022356570 cites W2013742343 @default.
• W2022356570 cites W2020506302 @default.
• W2022356570 cites W2021628061 @default.
• W2022356570 cites W2024651005 @default.
• W2022356570 cites W2025389130 @default.
• W2022356570 cites W2025980842 @default.
• W2022356570 cites W2028231353 @default.
• W2022356570 cites W2029748952 @default.
• W2022356570 cites W2031772330 @default.
• W2022356570 cites W2033488181 @default.
• W2022356570 cites W2034626992 @default.
• W2022356570 cites W2037644310 @default.
• W2022356570 cites W2038742557 @default.
• W2022356570 cites W2040194285 @default.
• W2022356570 cites W2043911313 @default.
• W2022356570 cites W2049184213 @default.
• W2022356570 cites W2049507332 @default.
• W2022356570 cites W2054720651 @default.
• W2022356570 cites W2058620780 @default.
• W2022356570 cites W2058675020 @default.
• W2022356570 cites W2060035159 @default.
• W2022356570 cites W2080528351 @default.
• W2022356570 cites W2084949662 @default.
• W2022356570 cites W2093477872 @default.
• W2022356570 cites W2095381863 @default.
• W2022356570 cites W2102273931 @default.
• W2022356570 cites W2106315897 @default.
• W2022356570 cites W2128307445 @default.
• W2022356570 cites W2133051701 @default.
• W2022356570 cites W2143600397 @default.
• W2022356570 cites W2150444353 @default.
• W2022356570 cites W2163352757 @default.
• W2022356570 cites W2164004507 @default.
• W2022356570 cites W2170629989 @default.
• W2022356570 cites W4211075026 @default.
• W2022356570 doi "https://doi.org/10.1016/j.str.2004.10.006" @default.
• W2022356570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15576039" @default.
• W2022356570 hasPublicationYear "2004" @default.
• W2022356570 type Work @default.
• W2022356570 sameAs 2022356570 @default.
• W2022356570 citedByCount "63" @default.
• W2022356570 countsByYear W20223565702012 @default.
• W2022356570 countsByYear W20223565702013 @default.
• W2022356570 countsByYear W20223565702014 @default.
• W2022356570 countsByYear W20223565702015 @default.
• W2022356570 countsByYear W20223565702017 @default.
• W2022356570 countsByYear W20223565702018 @default.
• W2022356570 countsByYear W20223565702019 @default.
• W2022356570 countsByYear W20223565702020 @default.
• W2022356570 countsByYear W20223565702021 @default.
• W2022356570 countsByYear W20223565702022 @default.
• W2022356570 countsByYear W20223565702023 @default.
• W2022356570 crossrefType "journal-article" @default.
• W2022356570 hasAuthorship W2022356570A5024642832 @default.
• W2022356570 hasAuthorship W2022356570A5031768744 @default.
• W2022356570 hasAuthorship W2022356570A5037671858 @default.
• W2022356570 hasBestOaLocation W20223565701 @default.
• W2022356570 hasConcept C101544691 @default.
• W2022356570 hasConcept C104317684 @default.
• W2022356570 hasConcept C118892022 @default.
• W2022356570 hasConcept C143065580 @default.
• W2022356570 hasConcept C170493617 @default.
• W2022356570 hasConcept C184235292 @default.
• W2022356570 hasConcept C185592680 @default.
• W2022356570 hasConcept C32619005 @default.
• W2022356570 hasConcept C42362537 @default.
• W2022356570 hasConcept C55493867 @default.
• W2022356570 hasConcept C62478195 @default.
• W2022356570 hasConcept C86803240 @default.
• W2022356570 hasConcept C95444343 @default.
• W2022356570 hasConceptScore W2022356570C101544691 @default.
• W2022356570 hasConceptScore W2022356570C104317684 @default.
• W2022356570 hasConceptScore W2022356570C118892022 @default.
• W2022356570 hasConceptScore W2022356570C143065580 @default.
• W2022356570 hasConceptScore W2022356570C170493617 @default.
• W2022356570 hasConceptScore W2022356570C184235292 @default.
• W2022356570 hasConceptScore W2022356570C185592680 @default.
• W2022356570 hasConceptScore W2022356570C32619005 @default.
• W2022356570 hasConceptScore W2022356570C42362537 @default.

• next