Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022356719> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2022356719 endingPage "A18" @default.
- W2022356719 startingPage "A17" @default.
- W2022356719 abstract "<h3>Background</h3> The incidence of contrast nephropathy (CIN) following coronary angiography or percutaneous coronary intervention (PCI) in patients with diabetes mellitus (DM) may be up to 30% and is associated with increased long term morbidity and mortality. <h3>Methods</h3> We recruited 208 consecutive patients undergoing elective or urgent coronary angiography or PCI with known DM and chronic kidney disease (CKD) (defined as eGFR <60 ml/min). CIN was defined as a post procedure rise in creatinine at day 3 of >25% from baseline or an absolute rise of 44.5 μmol/l. Severity of coronary disease was assessed using the SYNTAX Score and risk of CIN using the Mehran risk score. We evaluated serum and urine neutrophil gelatinase-associated lipocalin (NGAL) and albuminuria for additional information about CIN risk. N-acetylcysteine and intravenous hydration were given to all patients with eGFR <50 ml in accordance with local guidelines. <h3>Results</h3> Baseline characteristics are summarised in table 1. 116 patients underwent coronary angiography and 92 underwent PCI. 39 patients (18.8%) developed CIN. Contrast dose was similar in the CIN and non-CIN group (p=0.249). The Mehran risk score was strongly predictive of CIN development (p<0.001). The SYNTAX score did not differ between those who did or did not develop CIN (p=0.188). A significant rise in serum NGAL was seen as early as 2 h post procedure in the CIN arm (p=0.03) and this persisted at 4 h (p=0.007) and 12–24 h (p=0.0015). Urine NGAL levels did not change significantly during the first 24 h. Neither albumin:creatinine ratio (p=0.149) or protein:creatinine ratio (p=0.635) predicted development of CIN. <h3>Conclusions</h3> The current gold standard for measuring CIN is a rise in serum creatinine but this is of limited value as it does not increase until 48–72 h post renal injury. Neither the SYNTAX score, nor urinary albuminuria or proteinuria are predictive of CIN development. A rise in serum NGAL levels within the first 12 h following coronary angiography or PCI appears to be a very promising marker in the early diagnosis of CIN." @default.
- W2022356719 created "2016-06-24" @default.
- W2022356719 creator A5008830655 @default.
- W2022356719 creator A5019107719 @default.
- W2022356719 creator A5029861356 @default.
- W2022356719 creator A5039406185 @default.
- W2022356719 creator A5075552636 @default.
- W2022356719 creator A5006993725 @default.
- W2022356719 date "2011-06-01" @default.
- W2022356719 modified "2023-09-27" @default.
- W2022356719 title "23 Serum ngal identifies contrast nephropathy early in patients with diabetes mellitus and chronic kidney disease undergoing coronary angiography and angioplasty" @default.
- W2022356719 doi "https://doi.org/10.1136/heartjnl-2011-300198.23" @default.
- W2022356719 hasPublicationYear "2011" @default.
- W2022356719 type Work @default.
- W2022356719 sameAs 2022356719 @default.
- W2022356719 citedByCount "3" @default.
- W2022356719 countsByYear W20223567192015 @default.
- W2022356719 countsByYear W20223567192022 @default.
- W2022356719 countsByYear W20223567192023 @default.
- W2022356719 crossrefType "journal-article" @default.
- W2022356719 hasAuthorship W2022356719A5006993725 @default.
- W2022356719 hasAuthorship W2022356719A5008830655 @default.
- W2022356719 hasAuthorship W2022356719A5019107719 @default.
- W2022356719 hasAuthorship W2022356719A5029861356 @default.
- W2022356719 hasAuthorship W2022356719A5039406185 @default.
- W2022356719 hasAuthorship W2022356719A5075552636 @default.
- W2022356719 hasBestOaLocation W20223567191 @default.
- W2022356719 hasConcept C11783203 @default.
- W2022356719 hasConcept C126322002 @default.
- W2022356719 hasConcept C134018914 @default.
- W2022356719 hasConcept C141071460 @default.
- W2022356719 hasConcept C159641895 @default.
- W2022356719 hasConcept C164705383 @default.
- W2022356719 hasConcept C2776174234 @default.
- W2022356719 hasConcept C2778569047 @default.
- W2022356719 hasConcept C2778653478 @default.
- W2022356719 hasConcept C2779134260 @default.
- W2022356719 hasConcept C2780306776 @default.
- W2022356719 hasConcept C2780326628 @default.
- W2022356719 hasConcept C2780400711 @default.
- W2022356719 hasConcept C2781184683 @default.
- W2022356719 hasConcept C45393284 @default.
- W2022356719 hasConcept C500558357 @default.
- W2022356719 hasConcept C555293320 @default.
- W2022356719 hasConcept C71924100 @default.
- W2022356719 hasConceptScore W2022356719C11783203 @default.
- W2022356719 hasConceptScore W2022356719C126322002 @default.
- W2022356719 hasConceptScore W2022356719C134018914 @default.
- W2022356719 hasConceptScore W2022356719C141071460 @default.
- W2022356719 hasConceptScore W2022356719C159641895 @default.
- W2022356719 hasConceptScore W2022356719C164705383 @default.
- W2022356719 hasConceptScore W2022356719C2776174234 @default.
- W2022356719 hasConceptScore W2022356719C2778569047 @default.
- W2022356719 hasConceptScore W2022356719C2778653478 @default.
- W2022356719 hasConceptScore W2022356719C2779134260 @default.
- W2022356719 hasConceptScore W2022356719C2780306776 @default.
- W2022356719 hasConceptScore W2022356719C2780326628 @default.
- W2022356719 hasConceptScore W2022356719C2780400711 @default.
- W2022356719 hasConceptScore W2022356719C2781184683 @default.
- W2022356719 hasConceptScore W2022356719C45393284 @default.
- W2022356719 hasConceptScore W2022356719C500558357 @default.
- W2022356719 hasConceptScore W2022356719C555293320 @default.
- W2022356719 hasConceptScore W2022356719C71924100 @default.
- W2022356719 hasIssue "Suppl 1" @default.
- W2022356719 hasLocation W20223567191 @default.
- W2022356719 hasOpenAccess W2022356719 @default.
- W2022356719 hasPrimaryLocation W20223567191 @default.
- W2022356719 hasRelatedWork W1990881827 @default.
- W2022356719 hasRelatedWork W2305931352 @default.
- W2022356719 hasRelatedWork W2355705768 @default.
- W2022356719 hasRelatedWork W2384442202 @default.
- W2022356719 hasRelatedWork W2565326400 @default.
- W2022356719 hasRelatedWork W2790902759 @default.
- W2022356719 hasRelatedWork W2897830691 @default.
- W2022356719 hasRelatedWork W3029591959 @default.
- W2022356719 hasRelatedWork W3109207456 @default.
- W2022356719 hasRelatedWork W4292730663 @default.
- W2022356719 hasVolume "97" @default.
- W2022356719 isParatext "false" @default.
- W2022356719 isRetracted "false" @default.
- W2022356719 magId "2022356719" @default.
- W2022356719 workType "article" @default.