FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022357654> ?p ?o ?g. }

• W2022357654 endingPage "61" @default.
• W2022357654 startingPage "58" @default.
• W2022357654 abstract "The most commonly detected hypercoagulable state involves an abnormal factor V protein synthesized by the liver in which arginine at position 506 is replaced by glutamine as a result of a single-point mutation in the factor V gene (factor V Leiden). Liver transplantation is complicated by hepatic vascular thrombosis in up to 15% of cases, resulting in graft loss in most instances. This retrospective study examined the effect of the factor V Leiden mutation on the risk of hepatic vessel thrombosis after liver transplantation. The mutation was sought by polymerase chain reaction and Mnl I digestion of DNA where available from 214 recipients and 276 donors receiving 319 liver transplants. No donors or patients were homozygous for the factor V Leiden mutation. The prevalence of the heterozygous mutation was 19 of 276 (6.9%) in donors and 19 of 214 (8.9%) in recipients. Forty-one thrombotic episodes occurred after transplantation in the 276 transplants in which donor DNA was available for analysis; 22 involved the hepatic artery, 9 involved the portal vein, and 10 were deep venous thromboses. A donor factor V Leiden mutation was detected in the donor in 6 of 41 (14.6%) with any thrombotic event compared with 13 of 235 (5.5%) without (P = 0.03). The relative risk of any thrombosis with this mutation was therefore 2.32 (95% confidence interval [CI], 1.12–4.81). The factor V Leiden mutation was present in the donor in 4 of 31 (12.9%) cases complicated by hepatic vessel thrombosis (which always led to graft loss or death) and 15 of 245 (6.1%) cases without (P = 0.16). The relative risk of hepatic vessel thrombosis in the presence of this allele was therefore 2.00 (95% CI, 0.78–5.14). As anticipated, the presence of this allele in the recipient was not associated with deep venous or hepatic vessel thrombosis. The factor V Leiden mutation in the donor liver is not a major risk factor for hepatic vessel thrombosis and subsequent graft loss after liver transplantation." @default.
• W2022357654 created "2016-06-24" @default.
• W2022357654 creator A5010873271 @default.
• W2022357654 creator A5023799916 @default.
• W2022357654 creator A5034822694 @default.
• W2022357654 creator A5043820439 @default.
• W2022357654 creator A5054292368 @default.
• W2022357654 creator A5075313983 @default.
• W2022357654 creator A5085456195 @default.
• W2022357654 date "1998-01-01" @default.
• W2022357654 modified "2023-10-15" @default.
• W2022357654 title "Donor factor V leiden mutation and vascular thrombosis following liver transplantation" @default.
• W2022357654 cites W1965958910 @default.
• W2022357654 cites W1993729059 @default.
• W2022357654 cites W1995474189 @default.
• W2022357654 cites W2011297399 @default.
• W2022357654 cites W2011751129 @default.
• W2022357654 cites W2034557755 @default.
• W2022357654 cites W2061090667 @default.
• W2022357654 cites W2069126087 @default.
• W2022357654 cites W2069343109 @default.
• W2022357654 cites W2077770912 @default.
• W2022357654 cites W2081607015 @default.
• W2022357654 cites W2104062454 @default.
• W2022357654 cites W2105515856 @default.
• W2022357654 cites W2114918842 @default.
• W2022357654 cites W2354256664 @default.
• W2022357654 cites W2401560229 @default.
• W2022357654 cites W2414253260 @default.
• W2022357654 doi "https://doi.org/10.1002/lt.500040108" @default.
• W2022357654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9457968" @default.
• W2022357654 hasPublicationYear "1998" @default.
• W2022357654 type Work @default.
• W2022357654 sameAs 2022357654 @default.
• W2022357654 citedByCount "45" @default.
• W2022357654 countsByYear W20223576542012 @default.
• W2022357654 countsByYear W20223576542015 @default.
• W2022357654 countsByYear W20223576542017 @default.
• W2022357654 countsByYear W20223576542018 @default.
• W2022357654 countsByYear W20223576542021 @default.
• W2022357654 countsByYear W20223576542023 @default.
• W2022357654 crossrefType "journal-article" @default.
• W2022357654 hasAuthorship W2022357654A5010873271 @default.
• W2022357654 hasAuthorship W2022357654A5023799916 @default.
• W2022357654 hasAuthorship W2022357654A5034822694 @default.
• W2022357654 hasAuthorship W2022357654A5043820439 @default.
• W2022357654 hasAuthorship W2022357654A5054292368 @default.
• W2022357654 hasAuthorship W2022357654A5075313983 @default.
• W2022357654 hasAuthorship W2022357654A5085456195 @default.
• W2022357654 hasBestOaLocation W20223576541 @default.
• W2022357654 hasConcept C104317684 @default.
• W2022357654 hasConcept C126322002 @default.
• W2022357654 hasConcept C176944494 @default.
• W2022357654 hasConcept C2776046644 @default.
• W2022357654 hasConcept C2777175894 @default.
• W2022357654 hasConcept C2778800853 @default.
• W2022357654 hasConcept C2779609443 @default.
• W2022357654 hasConcept C2780011451 @default.
• W2022357654 hasConcept C2780868729 @default.
• W2022357654 hasConcept C2911091166 @default.
• W2022357654 hasConcept C501734568 @default.
• W2022357654 hasConcept C50440223 @default.
• W2022357654 hasConcept C54355233 @default.
• W2022357654 hasConcept C71924100 @default.
• W2022357654 hasConcept C86803240 @default.
• W2022357654 hasConcept C90924648 @default.
• W2022357654 hasConceptScore W2022357654C104317684 @default.
• W2022357654 hasConceptScore W2022357654C126322002 @default.
• W2022357654 hasConceptScore W2022357654C176944494 @default.
• W2022357654 hasConceptScore W2022357654C2776046644 @default.
• W2022357654 hasConceptScore W2022357654C2777175894 @default.
• W2022357654 hasConceptScore W2022357654C2778800853 @default.
• W2022357654 hasConceptScore W2022357654C2779609443 @default.
• W2022357654 hasConceptScore W2022357654C2780011451 @default.
• W2022357654 hasConceptScore W2022357654C2780868729 @default.
• W2022357654 hasConceptScore W2022357654C2911091166 @default.
• W2022357654 hasConceptScore W2022357654C501734568 @default.
• W2022357654 hasConceptScore W2022357654C50440223 @default.
• W2022357654 hasConceptScore W2022357654C54355233 @default.
• W2022357654 hasConceptScore W2022357654C71924100 @default.
• W2022357654 hasConceptScore W2022357654C86803240 @default.
• W2022357654 hasConceptScore W2022357654C90924648 @default.
• W2022357654 hasIssue "1" @default.
• W2022357654 hasLocation W20223576541 @default.
• W2022357654 hasLocation W20223576542 @default.
• W2022357654 hasOpenAccess W2022357654 @default.
• W2022357654 hasPrimaryLocation W20223576541 @default.
• W2022357654 hasRelatedWork W2018718026 @default.
• W2022357654 hasRelatedWork W2033816335 @default.
• W2022357654 hasRelatedWork W2077043650 @default.
• W2022357654 hasRelatedWork W2109654476 @default.
• W2022357654 hasRelatedWork W2128479550 @default.
• W2022357654 hasRelatedWork W2315976690 @default.
• W2022357654 hasRelatedWork W2414248457 @default.
• W2022357654 hasRelatedWork W2554611772 @default.
• W2022357654 hasRelatedWork W3122743826 @default.
• W2022357654 hasRelatedWork W4233055421 @default.
• W2022357654 hasVolume "4" @default.

• next