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- W2022357735 abstract "The polyamine biosynthetic pathway is an important drug target for the treatment of human African trypanosomiasis (HAT), raising interest in understanding polyamine function and their mechanism of regulation. Polyamine levels are tightly controlled in mammalian cells, but similar regulatory mechanisms appear absent in trypanosomes. Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which catalyzes a key step in the biosynthesis of the polyamine spermidine, is activated by dimerization with an inducible protein termed prozyme. Prozyme is an inactive paralog of the active AdoMetDC enzyme that evolved by gene duplication and is found only in the trypanosomatids. In Trypanosoma brucei, AdoMetDC activity appears to be controlled by regulation of prozyme protein levels, potentially at the translational level." @default.
- W2022357735 created "2016-06-24" @default.
- W2022357735 creator A5008866938 @default.
- W2022357735 creator A5036886971 @default.
- W2022357735 date "2012-02-01" @default.
- W2022357735 modified "2023-10-03" @default.
- W2022357735 title "Regulation and function of polyamines in African trypanosomes" @default.
- W2022357735 cites W1489656307 @default.
- W2022357735 cites W1547594908 @default.
- W2022357735 cites W1927828270 @default.
- W2022357735 cites W1964869212 @default.
- W2022357735 cites W1969151014 @default.
- W2022357735 cites W1973543110 @default.
- W2022357735 cites W1975523674 @default.
- W2022357735 cites W1977287855 @default.
- W2022357735 cites W1977853473 @default.
- W2022357735 cites W1984672754 @default.
- W2022357735 cites W1987150763 @default.
- W2022357735 cites W1989272848 @default.
- W2022357735 cites W1991407392 @default.
- W2022357735 cites W1991923259 @default.
- W2022357735 cites W1995982847 @default.
- W2022357735 cites W2004071571 @default.
- W2022357735 cites W2004481032 @default.
- W2022357735 cites W2005105006 @default.
- W2022357735 cites W2005678524 @default.
- W2022357735 cites W2012015421 @default.
- W2022357735 cites W2016359033 @default.
- W2022357735 cites W2017910406 @default.
- W2022357735 cites W2021129421 @default.
- W2022357735 cites W2025994995 @default.
- W2022357735 cites W2028336112 @default.
- W2022357735 cites W2033416430 @default.
- W2022357735 cites W2035535679 @default.
- W2022357735 cites W2039372756 @default.
- W2022357735 cites W2053396671 @default.
- W2022357735 cites W2053663394 @default.
- W2022357735 cites W2057604614 @default.
- W2022357735 cites W2058194275 @default.
- W2022357735 cites W2058602688 @default.
- W2022357735 cites W2059409142 @default.
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- W2022357735 cites W2064370916 @default.
- W2022357735 cites W2067142804 @default.
- W2022357735 cites W2072393435 @default.
- W2022357735 cites W2078010499 @default.
- W2022357735 cites W2083119952 @default.
- W2022357735 cites W2086004974 @default.
- W2022357735 cites W2090150963 @default.
- W2022357735 cites W2090301261 @default.
- W2022357735 cites W2091510265 @default.
- W2022357735 cites W2094707734 @default.
- W2022357735 cites W2095278895 @default.
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- W2022357735 cites W2101787581 @default.
- W2022357735 cites W2109134602 @default.
- W2022357735 cites W2112711937 @default.
- W2022357735 cites W2114232897 @default.
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- W2022357735 cites W2130509160 @default.
- W2022357735 cites W2135813076 @default.
- W2022357735 cites W2137317157 @default.
- W2022357735 cites W2141743919 @default.
- W2022357735 cites W2142266168 @default.
- W2022357735 cites W2146329417 @default.
- W2022357735 cites W2147621980 @default.
- W2022357735 cites W2148794173 @default.
- W2022357735 cites W2148813938 @default.
- W2022357735 cites W2149268709 @default.
- W2022357735 cites W2149922395 @default.
- W2022357735 cites W2151799620 @default.
- W2022357735 cites W2151877638 @default.
- W2022357735 cites W2154208393 @default.
- W2022357735 cites W2154261496 @default.
- W2022357735 cites W215516326 @default.
- W2022357735 cites W2155771090 @default.
- W2022357735 cites W2157739749 @default.
- W2022357735 cites W2158267918 @default.
- W2022357735 cites W2166895048 @default.
- W2022357735 cites W2168360174 @default.
- W2022357735 cites W2169901493 @default.
- W2022357735 cites W2170669779 @default.
- W2022357735 cites W2415329703 @default.
- W2022357735 cites W2467073157 @default.
- W2022357735 cites W4231700538 @default.
- W2022357735 doi "https://doi.org/10.1016/j.pt.2011.11.001" @default.
- W2022357735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22192816" @default.
- W2022357735 hasPublicationYear "2012" @default.
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