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- W2022357961 abstract "We have previously found that vitamin E (VE) has an ability to restore the decreased mitogen response of splenocytes in spontaneously hypertensive rats (SHR) as a model of aging. The aim of this study is to investigate whether high VE diet can restore the decreased mitogen response of splenocytes in SAM-P1 as mouse model of aging. Male SAM-P1 and -R1 as control, 9 months old, were fed control (50 mg VE/kg diet) or high VE diet (585 mg VE/kg diet). Male SAM-R1, 4 weeks old, were used as young control. After 4 weeks, they were killed under anesthesia and their cellular immune functions were assayed. There was no significant differense in serum VE concentration between old SAM-R1 and -P1. In addition, high VE diet induced the similar increase of serum VE concentration in both old SAM-R1 and -P1. Mitogen response of splenic lymphocytes with concanavalin A (Con A) was remarkably decreased in SAM-P1 compared with those of young and old SAM-R1. High VE diet did not have the ability to restore the decreased mitogen response of splenic lymphocytes in SAM-P1. The percentage of adherent cells, mainly macrophages (Mø), in splenocytes was also remarkably decreased in old SAM-P1. Furthermore, Mø isolated from splenocytes of SAM-P1 did not have the enhancing effect on proliferation of splenic lymphocytes from young SAM-R1. These results suggest that the decreased mitogen response of splenic lymphocytes in SAM-P1 is not restored by high VE diet and may be associated to the decreases of both number and function of Mø." @default.
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- W2022357961 date "1999-09-01" @default.
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- W2022357961 title "Decreased mitogen response of splenocytes in senescence accelerated mice (SAM-P1) is not restored by high vitamin E diet" @default.
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- W2022357961 doi "https://doi.org/10.1016/s0271-5317(99)00096-2" @default.
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