FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022358207> ?p ?o ?g. }

• W2022358207 endingPage "15" @default.
• W2022358207 startingPage "1" @default.
• W2022358207 abstract "Dystonia musculorum (dtJ/dtJ) mutant mice suffer from a degeneration of spinocerebellar tracts as well as a dystrophy of peripheral sensory tracts. This neurological mutant has been proposed as an animal model of human cerebellar ataxia, in particular of the Friedreich's type; thus, it was deemed of interest to examine the endogenous contents of dopamine (DA) and metabolites as well as the distribution of DA receptors of the D1 and D2 subtypes, in order to delimit the biochemical characteristics of this pathological disorder, and determine an eventual dopaminergic dysfunction in this mutant. Tissue DA and its major metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid and 3-methoxytyramine were measured by HPLC coupled to electrochemical detection in six cortical regions, in four divisions of rostral neostriatum and two halves of caudal neostriatum, as well as in olfactory bulb, nucleus accumbens, septum, amygdala, hippocampus, thalamus, hypothalamus, brainstem, cerebellum, substantia nigra, and ventral tegmental area. The only significant difference between dtJ/dtJ mice and wild-type controls was an increase in hypothalamic DA contents (+47%). Quantitative autoradiography with [3H]SCH23390 and [3H]raclopride, to label D1 and D2 receptors, respectively, revealed only moderate changes in receptor densities in a few localized regions. In dtJ/dtJ mutants, D1 receptor numbers were found to be higher in thalamus (+27%) as well as in the medio-dorsal (+16%) and in the latero-dorsal (+16%) quadrants of rostral neostriatum, while D2 receptor densities were greater in the medio-ventral (+32%) and the latero-dorsal (+17%) quadrants. The present results indicate an overall conservation of dopaminergic functions, albeit the few localized sites of increased D1 and D2 receptor densities, and that are seemingly independent of the DA innervation pattern, as revealed by the tissue measurements of DA and metabolites. They also rule out a major pathology linked to deficits in DA neurotransmission, and validate this mutant as an animal model of human cerebellar ataxia, probably of the Friedreich type. Synapse 37:1–15, 2000. © 2000 Wiley-Liss, Inc." @default.
• W2022358207 created "2016-06-24" @default.
• W2022358207 creator A5036002196 @default.
• W2022358207 creator A5036707975 @default.
• W2022358207 creator A5039678466 @default.
• W2022358207 creator A5076727678 @default.
• W2022358207 creator A5078471774 @default.
• W2022358207 date "2000-07-01" @default.
• W2022358207 modified "2023-10-03" @default.
• W2022358207 title "Dopamine D1 and D2 receptors in the forebrain ofDystonia musculorum mutant mice: An autoradiographic survey in relation to dopamine contents" @default.
• W2022358207 cites W1503918021 @default.
• W2022358207 cites W1589010475 @default.
• W2022358207 cites W1775749144 @default.
• W2022358207 cites W1884206649 @default.
• W2022358207 cites W1974453590 @default.
• W2022358207 cites W1976057672 @default.
• W2022358207 cites W1978420178 @default.
• W2022358207 cites W1978922896 @default.
• W2022358207 cites W1981522667 @default.
• W2022358207 cites W1982637005 @default.
• W2022358207 cites W1983358193 @default.
• W2022358207 cites W1992452432 @default.
• W2022358207 cites W1996498301 @default.
• W2022358207 cites W2001449178 @default.
• W2022358207 cites W2008489590 @default.
• W2022358207 cites W2011542286 @default.
• W2022358207 cites W2022649017 @default.
• W2022358207 cites W2028466783 @default.
• W2022358207 cites W2030905853 @default.
• W2022358207 cites W2031679440 @default.
• W2022358207 cites W2033770424 @default.
• W2022358207 cites W2034988988 @default.
• W2022358207 cites W2038203809 @default.
• W2022358207 cites W2038877552 @default.
• W2022358207 cites W2042347677 @default.
• W2022358207 cites W2045629032 @default.
• W2022358207 cites W2053521749 @default.
• W2022358207 cites W2055092539 @default.
• W2022358207 cites W2064850602 @default.
• W2022358207 cites W2068020919 @default.
• W2022358207 cites W2068346256 @default.
• W2022358207 cites W2072891168 @default.
• W2022358207 cites W2073157918 @default.
• W2022358207 cites W2073685644 @default.
• W2022358207 cites W2076594625 @default.
• W2022358207 cites W2077760177 @default.
• W2022358207 cites W2080221541 @default.
• W2022358207 cites W2086222082 @default.
• W2022358207 cites W2092792572 @default.
• W2022358207 cites W2108717399 @default.
• W2022358207 cites W2114140596 @default.
• W2022358207 cites W2127087784 @default.
• W2022358207 cites W2150807108 @default.
• W2022358207 cites W2155136811 @default.
• W2022358207 cites W2166450724 @default.
• W2022358207 cites W2179259141 @default.
• W2022358207 cites W2325090502 @default.
• W2022358207 cites W2400774357 @default.
• W2022358207 cites W2406595647 @default.
• W2022358207 cites W2418325597 @default.
• W2022358207 cites W4211030769 @default.
• W2022358207 doi "https://doi.org/10.1002/(sici)1098-2396(200007)37:1<1::aid-syn1>3.0.co;2-9" @default.
• W2022358207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10842346" @default.
• W2022358207 hasPublicationYear "2000" @default.
• W2022358207 type Work @default.
• W2022358207 sameAs 2022358207 @default.
• W2022358207 citedByCount "20" @default.
• W2022358207 countsByYear W20223582072012 @default.
• W2022358207 countsByYear W20223582072018 @default.
• W2022358207 countsByYear W20223582072023 @default.
• W2022358207 crossrefType "journal-article" @default.
• W2022358207 hasAuthorship W2022358207A5036002196 @default.
• W2022358207 hasAuthorship W2022358207A5036707975 @default.
• W2022358207 hasAuthorship W2022358207A5039678466 @default.
• W2022358207 hasAuthorship W2022358207A5076727678 @default.
• W2022358207 hasAuthorship W2022358207A5078471774 @default.
• W2022358207 hasConcept C110726550 @default.
• W2022358207 hasConcept C120069818 @default.
• W2022358207 hasConcept C120750228 @default.
• W2022358207 hasConcept C126322002 @default.
• W2022358207 hasConcept C134018914 @default.
• W2022358207 hasConcept C169760540 @default.
• W2022358207 hasConcept C170493617 @default.
• W2022358207 hasConcept C185592680 @default.
• W2022358207 hasConcept C2775841634 @default.
• W2022358207 hasConcept C2775864247 @default.
• W2022358207 hasConcept C2776552330 @default.
• W2022358207 hasConcept C513476851 @default.
• W2022358207 hasConcept C71924100 @default.
• W2022358207 hasConcept C86803240 @default.
• W2022358207 hasConceptScore W2022358207C110726550 @default.
• W2022358207 hasConceptScore W2022358207C120069818 @default.
• W2022358207 hasConceptScore W2022358207C120750228 @default.
• W2022358207 hasConceptScore W2022358207C126322002 @default.
• W2022358207 hasConceptScore W2022358207C134018914 @default.
• W2022358207 hasConceptScore W2022358207C169760540 @default.
• W2022358207 hasConceptScore W2022358207C170493617 @default.
• W2022358207 hasConceptScore W2022358207C185592680 @default.

• next