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- W2022359747 abstract "Chronic, non-acute inflammation is behind conditions that represent most of the disease burden in humans and is clearly linked to immune and metabolic mechanisms. The convergence of pathways involving the immune response, oxidative stress, increased circulating lipids and aberrant insulin signaling results in CCL2-associated macrophage recruitment and altered energy metabolism. The CCL2/CCR2 pathway and the energy sensor AMP-activated protein kinase (AMPK) are attractive therapeutic targets as a part of preventive management of disease. Several effects of polyphenols are useful in this scenario, including a reduction in the activities of cytokines and modulation of cellular metabolism through histone deacetylase inhibitors, AMPK activators, calorie-restriction mimetics or epigenetic regulators. Research is currently underway to develop orally active drugs with these effects, but it is convenient to examine more closely what we are eating. If a lack of relevance in terms of toxicity and substantial effectiveness are confirmed, plant-derived components may provide useful druggable components and dietary supplements. We consider therapeutic actions as a combination of synergistic and/or antagonistic interactions in a multi-target strategy. Hence, improvement in food through enrichment with polyphenols with demonstrated activity may represent a major advance in the design of diets with both industrial and sanitary value." @default.
- W2022359747 created "2016-06-24" @default.
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- W2022359747 date "2013-01-01" @default.
- W2022359747 modified "2023-10-07" @default.
- W2022359747 title "Multifunctional targets of dietary polyphenols in disease: A case for the chemokine network and energy metabolism" @default.
- W2022359747 cites W1491443798 @default.
- W2022359747 cites W157402533 @default.
- W2022359747 cites W1589463485 @default.
- W2022359747 cites W1592483428 @default.
- W2022359747 cites W1593760300 @default.
- W2022359747 cites W1602000691 @default.
- W2022359747 cites W1667820694 @default.
- W2022359747 cites W1702423934 @default.
- W2022359747 cites W1821237400 @default.
- W2022359747 cites W1963740353 @default.
- W2022359747 cites W1963904011 @default.
- W2022359747 cites W1966376169 @default.
- W2022359747 cites W1968302053 @default.
- W2022359747 cites W1968962983 @default.
- W2022359747 cites W1970170374 @default.
- W2022359747 cites W1970930356 @default.
- W2022359747 cites W1972091423 @default.
- W2022359747 cites W1972248486 @default.
- W2022359747 cites W1972483153 @default.
- W2022359747 cites W1973220859 @default.
- W2022359747 cites W1974033843 @default.
- W2022359747 cites W1974370294 @default.
- W2022359747 cites W1974560134 @default.
- W2022359747 cites W1974813621 @default.
- W2022359747 cites W1976184705 @default.
- W2022359747 cites W1977267072 @default.
- W2022359747 cites W1979223116 @default.
- W2022359747 cites W1980485769 @default.
- W2022359747 cites W1981343290 @default.
- W2022359747 cites W1982504657 @default.
- W2022359747 cites W1983279602 @default.
- W2022359747 cites W1983603161 @default.
- W2022359747 cites W1984283228 @default.
- W2022359747 cites W1984736455 @default.
- W2022359747 cites W1987874136 @default.
- W2022359747 cites W1988402383 @default.
- W2022359747 cites W1990791836 @default.
- W2022359747 cites W1992915466 @default.
- W2022359747 cites W1993132387 @default.
- W2022359747 cites W1994353903 @default.
- W2022359747 cites W1995849115 @default.
- W2022359747 cites W1995933090 @default.
- W2022359747 cites W1996404449 @default.
- W2022359747 cites W1996854381 @default.
- W2022359747 cites W1998875272 @default.
- W2022359747 cites W1998927777 @default.
- W2022359747 cites W1999913420 @default.
- W2022359747 cites W2000078648 @default.
- W2022359747 cites W2000180786 @default.
- W2022359747 cites W2002584410 @default.
- W2022359747 cites W2007750854 @default.
- W2022359747 cites W2010924937 @default.
- W2022359747 cites W2013528879 @default.
- W2022359747 cites W2018173754 @default.
- W2022359747 cites W2021427703 @default.
- W2022359747 cites W2023913067 @default.
- W2022359747 cites W2025228932 @default.
- W2022359747 cites W2026967508 @default.
- W2022359747 cites W2027033448 @default.
- W2022359747 cites W2027696763 @default.
- W2022359747 cites W2027922456 @default.
- W2022359747 cites W2028536701 @default.
- W2022359747 cites W2031855999 @default.
- W2022359747 cites W2033591223 @default.
- W2022359747 cites W2033896075 @default.
- W2022359747 cites W2034825007 @default.
- W2022359747 cites W2035993869 @default.
- W2022359747 cites W2037566407 @default.
- W2022359747 cites W2038440449 @default.
- W2022359747 cites W2039337821 @default.
- W2022359747 cites W2040209538 @default.
- W2022359747 cites W2040695321 @default.
- W2022359747 cites W2043156936 @default.
- W2022359747 cites W2043498277 @default.
- W2022359747 cites W2044025814 @default.
- W2022359747 cites W2046021057 @default.
- W2022359747 cites W2048632662 @default.
- W2022359747 cites W2048695976 @default.
- W2022359747 cites W2049848613 @default.
- W2022359747 cites W2050923912 @default.
- W2022359747 cites W2052496989 @default.
- W2022359747 cites W2053073250 @default.