FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022359905> ?p ?o ?g. }

• W2022359905 endingPage "465" @default.
• W2022359905 startingPage "455" @default.
• W2022359905 abstract "Interleukin-17 (IL-17) is a proinflammatory cytokine that plays an important role in clearing extracellular bacteria and contributes to the pathology of many autoimmune and allergic conditions. In the present study, five novel IL-17 homologs were identified by searching and analyzing the Pacific oyster genome. All six CgIL-17 members (including a previously reported homolog) contained four conserved cysteines that were used in the formation of disulfide bonds. Phylogenetic analysis showed that all invertebrate IL-17s were clustered into one group, implying that invertebrate IL-17s evolved from one common ancestral gene and subsequently diversified. All CgIL-17s shared the same genomic structure, containing two exons and one intron, except for the CgIL-17-3 and CgIL-17-5 genes, which each had only one exon. The expression pattern of the CgIL-17 genes was analyzed by qRT-PCR in a variety of tissues and at different developmental stages, and these genes were highly expressed in the gill and digestive gland tissues. Moreover, the expression of the CgIL-17 family genes was significantly up-regulated in hemocytes challenged with Pathogen-Associated Molecular Patterns (PAMPs). CgIL-17-3 had a strong response to lipopolysaccharide (LPS) and heat-killed Vibrio alginolyticus (HKVA) challenge, while CgIL-17-5 and CgIL-17-6 can be activated by peptidoglycan (PGN), but not by heat-killed Listeria monocytogenes (HKLM). The distinct, up-regulated transcript levels of the CgIL-17s in response to PAMPs challenge further indicate that CgIL-17s are likely to be significant components of immune responses by playing diversified roles in host defense in the Pacific oyster. These findings suggest that CgIL-17s are involved in innate immune responses and further supports their conserved function in mollusks immunity." @default.
• W2022359905 created "2016-06-24" @default.
• W2022359905 creator A5019118326 @default.
• W2022359905 creator A5022802322 @default.
• W2022359905 creator A5027835055 @default.
• W2022359905 creator A5048491040 @default.
• W2022359905 creator A5048491053 @default.
• W2022359905 creator A5053819992 @default.
• W2022359905 creator A5086759438 @default.
• W2022359905 date "2014-10-01" @default.
• W2022359905 modified "2023-10-12" @default.
• W2022359905 title "Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas" @default.
• W2022359905 cites W1524387625 @default.
• W2022359905 cites W1537128240 @default.
• W2022359905 cites W1542734258 @default.
• W2022359905 cites W1568265476 @default.
• W2022359905 cites W1577577364 @default.
• W2022359905 cites W1602835962 @default.
• W2022359905 cites W1977105764 @default.
• W2022359905 cites W1983135466 @default.
• W2022359905 cites W1984420944 @default.
• W2022359905 cites W1991407027 @default.
• W2022359905 cites W2000024124 @default.
• W2022359905 cites W2007848971 @default.
• W2022359905 cites W2011563426 @default.
• W2022359905 cites W2011847208 @default.
• W2022359905 cites W2012300428 @default.
• W2022359905 cites W2014730185 @default.
• W2022359905 cites W2020233428 @default.
• W2022359905 cites W2023686229 @default.
• W2022359905 cites W2026345779 @default.
• W2022359905 cites W2033454860 @default.
• W2022359905 cites W2039416679 @default.
• W2022359905 cites W2041489554 @default.
• W2022359905 cites W2043258872 @default.
• W2022359905 cites W2045611262 @default.
• W2022359905 cites W2053888978 @default.
• W2022359905 cites W2055895291 @default.
• W2022359905 cites W2060198845 @default.
• W2022359905 cites W2060527543 @default.
• W2022359905 cites W2065136791 @default.
• W2022359905 cites W2072055489 @default.
• W2022359905 cites W2073313785 @default.
• W2022359905 cites W2073441708 @default.
• W2022359905 cites W2102621913 @default.
• W2022359905 cites W2106651030 @default.
• W2022359905 cites W2107997395 @default.
• W2022359905 cites W2108615089 @default.
• W2022359905 cites W2109483293 @default.
• W2022359905 cites W2111914463 @default.
• W2022359905 cites W2115631255 @default.
• W2022359905 cites W2116736571 @default.
• W2022359905 cites W2130887303 @default.
• W2022359905 cites W2142695752 @default.
• W2022359905 cites W2147838733 @default.
• W2022359905 cites W2149471901 @default.
• W2022359905 cites W2152994600 @default.
• W2022359905 cites W2166313509 @default.
• W2022359905 cites W2168784669 @default.
• W2022359905 doi "https://doi.org/10.1016/j.fsi.2014.07.026" @default.
• W2022359905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25090939" @default.
• W2022359905 hasPublicationYear "2014" @default.
• W2022359905 type Work @default.
• W2022359905 sameAs 2022359905 @default.
• W2022359905 citedByCount "66" @default.
• W2022359905 countsByYear W20223599052015 @default.
• W2022359905 countsByYear W20223599052016 @default.
• W2022359905 countsByYear W20223599052017 @default.
• W2022359905 countsByYear W20223599052018 @default.
• W2022359905 countsByYear W20223599052019 @default.
• W2022359905 countsByYear W20223599052020 @default.
• W2022359905 countsByYear W20223599052021 @default.
• W2022359905 countsByYear W20223599052022 @default.
• W2022359905 countsByYear W20223599052023 @default.
• W2022359905 crossrefType "journal-article" @default.
• W2022359905 hasAuthorship W2022359905A5019118326 @default.
• W2022359905 hasAuthorship W2022359905A5022802322 @default.
• W2022359905 hasAuthorship W2022359905A5027835055 @default.
• W2022359905 hasAuthorship W2022359905A5048491040 @default.
• W2022359905 hasAuthorship W2022359905A5048491053 @default.
• W2022359905 hasAuthorship W2022359905A5053819992 @default.
• W2022359905 hasAuthorship W2022359905A5086759438 @default.
• W2022359905 hasConcept C104317684 @default.
• W2022359905 hasConcept C141231307 @default.
• W2022359905 hasConcept C2776364969 @default.
• W2022359905 hasConcept C2776845067 @default.
• W2022359905 hasConcept C2781047198 @default.
• W2022359905 hasConcept C36823959 @default.
• W2022359905 hasConcept C505870484 @default.
• W2022359905 hasConcept C54355233 @default.
• W2022359905 hasConcept C5911399 @default.
• W2022359905 hasConcept C86803240 @default.
• W2022359905 hasConcept C94671646 @default.
• W2022359905 hasConceptScore W2022359905C104317684 @default.
• W2022359905 hasConceptScore W2022359905C141231307 @default.
• W2022359905 hasConceptScore W2022359905C2776364969 @default.
• W2022359905 hasConceptScore W2022359905C2776845067 @default.
• W2022359905 hasConceptScore W2022359905C2781047198 @default.

• next