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- W2022360182 abstract "Purpose of review Tubule repair following acute kidney injury involves epithelial de-differentiation followed by cell migration and proliferation and eventual re-differentiation. This review describes our understanding of how that process is regulated. Recent findings Epithelial de-differentiation after kidney injury or in epithelial culture systems is controlled by secreted factors such as transforming growth factor β and hepatocyte growth factor as well as cell–cell and cell–matrix interactions. These surface signals stimulate intracellular signaling via the mitogen-activated protein kinase, phosphoinositide-3-kinase, and Wnt/β-catenin pathways that in turn activate the morphologic and transcriptional events involved in cell spreading, migration, and proliferation. As cell confluency increases during the repair process, and the factors stimulating de-differentiation are suppressed, these morphogenic programs are downregulated and signals to promote re-differentiation are activated. Summary This review focuses on the underlying molecular mechanism of epithelial de-differentiation and re-differentiation in tubule repair in vivo and formation in vitro, thus giving insight into possible strategies for improving recovery following acute kidney injury and preventing progression to chronic kidney disease." @default.
- W2022360182 created "2016-06-24" @default.
- W2022360182 creator A5053840136 @default.
- W2022360182 creator A5087257594 @default.
- W2022360182 date "2008-07-01" @default.
- W2022360182 modified "2023-10-16" @default.
- W2022360182 title "Epithelial???mesenchymal???epithelial cycling in kidney repair" @default.
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- W2022360182 doi "https://doi.org/10.1097/mnh.0b013e3283046507" @default.
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