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• W2022360503 abstract "microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Furthermore, miR-489 could regulate SUZ12 as shown by luciferase reporter and Western blot assays. Aberrant miR-489 expression could regulate the molecular changes (E-cadherin, N-cadherin, and Vimentin) of epithelial mesenchymal transition (EMT). In conclusion, our study revealed that miR-489 may play an essential role in the progression of NSCLC." @default.
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• W2022360503 date "2015-04-02" @default.
• W2022360503 modified "2023-10-04" @default.
• W2022360503 title "Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12" @default.
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• W2022360503 doi "https://doi.org/10.1007/s13277-015-3340-3" @default.
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