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- W2022361377 abstract "Granulocyte colony-stimulating factor (G-CSF) protects neurons against experimental focal cerebral ischemia. However, its neuroprotective effect on human brain is unknown. We sought to determine whether G-CSF can protect the human cerebral neurons in vitro. Human cerebral-neuroblastoma hybrid cell line (A1) was exposed to oxygen and glucose deprivation with or without G-CSF. G-CSF promoted cell survival and decreased cytotoxicity effectively at 25 ng/ml. G-CSF reduced early apoptotic (annexin V+/PI−), and late apoptotic or necrotic (annexin V+/PI+) cells, and decreased active caspase-3 immunoreactivity. G-CSF could protect human cerebral neurons following in vitro ischemia." @default.
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- W2022361377 date "2006-02-01" @default.
- W2022361377 modified "2023-10-16" @default.
- W2022361377 title "G-CSF protects human cerebral hybrid neurons against in vitro ischemia" @default.
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- W2022361377 doi "https://doi.org/10.1016/j.neulet.2005.10.040" @default.
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