Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022361761> ?p ?o ?g. }
- W2022361761 endingPage "9339" @default.
- W2022361761 startingPage "9335" @default.
- W2022361761 abstract "The mechanisms contributing to the development of autoimmune insulin-dependent diabetes mellitus have been analyzed in allophenic mouse chimeras of the NOD in equilibrium with C57BL/6 strain combination (where NOD is nonobese diabetic). Occurrence of lymphoid cell infiltration (insulitis) in pancreatic islets was observed in the majority of such chimeras. The development of insulitis was found to correlate with major histocompatibility complex chimerism in lymphoid cells and in thymus cortical regions. Chimeras with more than 50% of C57BL/6 lymphoid cells rarely developed insulitis. Our data suggest that the correlation with the thymic cortical region is absolute. Thus, all individuals displaying NOD or NOD/C57BL/6 thymic cortical regions developed insulitis, whereas we have not observed insulitis in chimeras with only C57BL/6 thymic cortical regions. Thus the positive selection of T cells appears to play a crucial role in the development of insulin-dependent diabetes mellitus." @default.
- W2022361761 created "2016-06-24" @default.
- W2022361761 creator A5008999114 @default.
- W2022361761 creator A5024801594 @default.
- W2022361761 creator A5038775949 @default.
- W2022361761 creator A5057502296 @default.
- W2022361761 creator A5057937091 @default.
- W2022361761 date "1991-10-15" @default.
- W2022361761 modified "2023-09-27" @default.
- W2022361761 title "The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras." @default.
- W2022361761 cites W1489208584 @default.
- W2022361761 cites W1502366909 @default.
- W2022361761 cites W1547913407 @default.
- W2022361761 cites W1576688622 @default.
- W2022361761 cites W1656371604 @default.
- W2022361761 cites W1964253805 @default.
- W2022361761 cites W1967238445 @default.
- W2022361761 cites W1972354503 @default.
- W2022361761 cites W1972726282 @default.
- W2022361761 cites W1972953398 @default.
- W2022361761 cites W1973485458 @default.
- W2022361761 cites W1988147435 @default.
- W2022361761 cites W1998531275 @default.
- W2022361761 cites W2005096752 @default.
- W2022361761 cites W2007362831 @default.
- W2022361761 cites W2007461616 @default.
- W2022361761 cites W2008775295 @default.
- W2022361761 cites W2011353877 @default.
- W2022361761 cites W2017069015 @default.
- W2022361761 cites W2027552805 @default.
- W2022361761 cites W2029060163 @default.
- W2022361761 cites W2036314272 @default.
- W2022361761 cites W2039319944 @default.
- W2022361761 cites W2043252168 @default.
- W2022361761 cites W2050717941 @default.
- W2022361761 cites W2053278781 @default.
- W2022361761 cites W2054126901 @default.
- W2022361761 cites W2056164065 @default.
- W2022361761 cites W2056828445 @default.
- W2022361761 cites W2056927502 @default.
- W2022361761 cites W2058796077 @default.
- W2022361761 cites W2079490247 @default.
- W2022361761 cites W2080153394 @default.
- W2022361761 cites W2086994045 @default.
- W2022361761 cites W2098698378 @default.
- W2022361761 cites W2122893430 @default.
- W2022361761 cites W2126323534 @default.
- W2022361761 cites W2140443312 @default.
- W2022361761 cites W2152409937 @default.
- W2022361761 cites W2158081754 @default.
- W2022361761 cites W2167102170 @default.
- W2022361761 cites W2339732924 @default.
- W2022361761 doi "https://doi.org/10.1073/pnas.88.20.9335" @default.
- W2022361761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/52709" @default.
- W2022361761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1924397" @default.
- W2022361761 hasPublicationYear "1991" @default.
- W2022361761 type Work @default.
- W2022361761 sameAs 2022361761 @default.
- W2022361761 citedByCount "20" @default.
- W2022361761 crossrefType "journal-article" @default.
- W2022361761 hasAuthorship W2022361761A5008999114 @default.
- W2022361761 hasAuthorship W2022361761A5024801594 @default.
- W2022361761 hasAuthorship W2022361761A5038775949 @default.
- W2022361761 hasAuthorship W2022361761A5057502296 @default.
- W2022361761 hasAuthorship W2022361761A5057937091 @default.
- W2022361761 hasBestOaLocation W20223617612 @default.
- W2022361761 hasConcept C104317684 @default.
- W2022361761 hasConcept C127716648 @default.
- W2022361761 hasConcept C134018914 @default.
- W2022361761 hasConcept C181152851 @default.
- W2022361761 hasConcept C203014093 @default.
- W2022361761 hasConcept C207936829 @default.
- W2022361761 hasConcept C2778013207 @default.
- W2022361761 hasConcept C2779511750 @default.
- W2022361761 hasConcept C30278631 @default.
- W2022361761 hasConcept C54355233 @default.
- W2022361761 hasConcept C555293320 @default.
- W2022361761 hasConcept C55851684 @default.
- W2022361761 hasConcept C86803240 @default.
- W2022361761 hasConcept C8891405 @default.
- W2022361761 hasConceptScore W2022361761C104317684 @default.
- W2022361761 hasConceptScore W2022361761C127716648 @default.
- W2022361761 hasConceptScore W2022361761C134018914 @default.
- W2022361761 hasConceptScore W2022361761C181152851 @default.
- W2022361761 hasConceptScore W2022361761C203014093 @default.
- W2022361761 hasConceptScore W2022361761C207936829 @default.
- W2022361761 hasConceptScore W2022361761C2778013207 @default.
- W2022361761 hasConceptScore W2022361761C2779511750 @default.
- W2022361761 hasConceptScore W2022361761C30278631 @default.
- W2022361761 hasConceptScore W2022361761C54355233 @default.
- W2022361761 hasConceptScore W2022361761C555293320 @default.
- W2022361761 hasConceptScore W2022361761C55851684 @default.
- W2022361761 hasConceptScore W2022361761C86803240 @default.
- W2022361761 hasConceptScore W2022361761C8891405 @default.
- W2022361761 hasIssue "20" @default.
- W2022361761 hasLocation W20223617611 @default.
- W2022361761 hasLocation W20223617612 @default.
- W2022361761 hasLocation W20223617613 @default.