FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022362200> ?p ?o ?g. }

• W2022362200 endingPage "912" @default.
• W2022362200 startingPage "900" @default.
• W2022362200 abstract "The kinetics of colchicine uptake into Chinese hamster ovary cells have been investigated and found to be consistent with an unmediated diffusion mode. A variety of compounds such as local anesthetics and non-ionic detergents as well as drugs such as vinblastine, vincristine, daunomycin and actinomycin D potentiate the rate of colchicine uptake into these cells and into colchicine resistant mutants. In all cases, higher concentrations of these compounds were required to stimulate colchicine uptake in the colchicine resistant mutants than in the cells of the parental line. This stimulation was observed also in the uptake of puromycin, a structurally and functionally different drug. These stimulatory agents did not, however, cause the cells to become nonspecifically leaky since the uptake of 2-deoxy-d-glucose was unaffected. In addition, the activation energy of colchicine uptake was unaltered in the presence of stimulating agents, implying that they were not causing colchicine to enter the cells via a different mechanism. The results are compatible with the view that these compounds are membrane-active, and are able to stimulate an increased rate of unmediated diffusion of colchicine into the cells. It appears that a mechanism for the regulation of passive permeability is modified in the resistant mutants." @default.
• W2022362200 created "2016-06-24" @default.
• W2022362200 creator A5004502540 @default.
• W2022362200 creator A5051827745 @default.
• W2022362200 creator A5070484872 @default.
• W2022362200 date "1976-12-01" @default.
• W2022362200 modified "2023-10-15" @default.
• W2022362200 title "Modulation of membrane drug permeability in Chinese hamster ovary cells" @default.
• W2022362200 cites W1598643903 @default.
• W2022362200 cites W1775749144 @default.
• W2022362200 cites W1966404579 @default.
• W2022362200 cites W1970208709 @default.
• W2022362200 cites W1973349939 @default.
• W2022362200 cites W1973703754 @default.
• W2022362200 cites W1974448889 @default.
• W2022362200 cites W1977521575 @default.
• W2022362200 cites W1984516227 @default.
• W2022362200 cites W1984875090 @default.
• W2022362200 cites W1990583841 @default.
• W2022362200 cites W1998413052 @default.
• W2022362200 cites W2005429288 @default.
• W2022362200 cites W2034031399 @default.
• W2022362200 cites W2040203716 @default.
• W2022362200 cites W2065275202 @default.
• W2022362200 cites W2076851988 @default.
• W2022362200 cites W2077227514 @default.
• W2022362200 cites W2080908360 @default.
• W2022362200 cites W2081567144 @default.
• W2022362200 cites W2088184536 @default.
• W2022362200 cites W2132433230 @default.
• W2022362200 doi "https://doi.org/10.1016/0005-2736(76)90059-6" @default.
• W2022362200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/999943" @default.
• W2022362200 hasPublicationYear "1976" @default.
• W2022362200 type Work @default.
• W2022362200 sameAs 2022362200 @default.
• W2022362200 citedByCount "94" @default.
• W2022362200 countsByYear W20223622002012 @default.
• W2022362200 countsByYear W20223622002015 @default.
• W2022362200 countsByYear W20223622002017 @default.
• W2022362200 countsByYear W20223622002020 @default.
• W2022362200 crossrefType "journal-article" @default.
• W2022362200 hasAuthorship W2022362200A5004502540 @default.
• W2022362200 hasAuthorship W2022362200A5051827745 @default.
• W2022362200 hasAuthorship W2022362200A5070484872 @default.
• W2022362200 hasConcept C104317684 @default.
• W2022362200 hasConcept C12554922 @default.
• W2022362200 hasConcept C134018914 @default.
• W2022362200 hasConcept C143065580 @default.
• W2022362200 hasConcept C170493617 @default.
• W2022362200 hasConcept C175656101 @default.
• W2022362200 hasConcept C185592680 @default.
• W2022362200 hasConcept C202751555 @default.
• W2022362200 hasConcept C24998067 @default.
• W2022362200 hasConcept C2776120743 @default.
• W2022362200 hasConcept C2776636253 @default.
• W2022362200 hasConcept C2776694085 @default.
• W2022362200 hasConcept C2777132456 @default.
• W2022362200 hasConcept C2778143360 @default.
• W2022362200 hasConcept C2779200571 @default.
• W2022362200 hasConcept C2781303535 @default.
• W2022362200 hasConcept C2992270614 @default.
• W2022362200 hasConcept C3675279 @default.
• W2022362200 hasConcept C41625074 @default.
• W2022362200 hasConcept C54355233 @default.
• W2022362200 hasConcept C55493867 @default.
• W2022362200 hasConcept C71240020 @default.
• W2022362200 hasConcept C86803240 @default.
• W2022362200 hasConcept C95444343 @default.
• W2022362200 hasConcept C98274493 @default.
• W2022362200 hasConceptScore W2022362200C104317684 @default.
• W2022362200 hasConceptScore W2022362200C12554922 @default.
• W2022362200 hasConceptScore W2022362200C134018914 @default.
• W2022362200 hasConceptScore W2022362200C143065580 @default.
• W2022362200 hasConceptScore W2022362200C170493617 @default.
• W2022362200 hasConceptScore W2022362200C175656101 @default.
• W2022362200 hasConceptScore W2022362200C185592680 @default.
• W2022362200 hasConceptScore W2022362200C202751555 @default.
• W2022362200 hasConceptScore W2022362200C24998067 @default.
• W2022362200 hasConceptScore W2022362200C2776120743 @default.
• W2022362200 hasConceptScore W2022362200C2776636253 @default.
• W2022362200 hasConceptScore W2022362200C2776694085 @default.
• W2022362200 hasConceptScore W2022362200C2777132456 @default.
• W2022362200 hasConceptScore W2022362200C2778143360 @default.
• W2022362200 hasConceptScore W2022362200C2779200571 @default.
• W2022362200 hasConceptScore W2022362200C2781303535 @default.
• W2022362200 hasConceptScore W2022362200C2992270614 @default.
• W2022362200 hasConceptScore W2022362200C3675279 @default.
• W2022362200 hasConceptScore W2022362200C41625074 @default.
• W2022362200 hasConceptScore W2022362200C54355233 @default.
• W2022362200 hasConceptScore W2022362200C55493867 @default.
• W2022362200 hasConceptScore W2022362200C71240020 @default.
• W2022362200 hasConceptScore W2022362200C86803240 @default.
• W2022362200 hasConceptScore W2022362200C95444343 @default.
• W2022362200 hasConceptScore W2022362200C98274493 @default.
• W2022362200 hasIssue "3" @default.
• W2022362200 hasLocation W20223622001 @default.
• W2022362200 hasLocation W20223622002 @default.
• W2022362200 hasOpenAccess W2022362200 @default.

• next