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• W2022362212 endingPage "93" @default.
• W2022362212 startingPage "84" @default.
• W2022362212 abstract "After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-mediated neuroprotective mechanism (adaptive immunity) that is amenable to boosting. We postulate that the beneficial or destructive outcome of the local microglial (innate) response is determined by a well-controlled dialog between the innate and the adaptive immune players. Here, we show that spontaneous or exogenously boosted T cell-mediated neuroprotection is correlated with early activation of microglia as antigen-presenting cells. We suggest that such microglial activity, if well controlled, is a crucial step in determining the fate of the neurons in a hostile environment." @default.
• W2022362212 created "2016-06-24" @default.
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• W2022362212 date "2004-01-01" @default.
• W2022362212 modified "2023-10-16" @default.
• W2022362212 title "Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system" @default.
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• W2022362212 doi "https://doi.org/10.1016/j.jneuroim.2003.10.049" @default.
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