FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022362978> ?p ?o ?g. }

• W2022362978 endingPage "664" @default.
• W2022362978 startingPage "653" @default.
• W2022362978 abstract "Disruption of reproductive function is a hallmark of abuse of anabolic androgenic steroids (AAS) in female subjects. To understand the central actions of AAS, patch clamp recordings were made in estrous, diestrous and AAS-treated mice from gonadotropin releasing hormone (GnRH) neurons, neurons in the medial preoptic area (mPOA) and neurons in the anteroventroperiventricular nucleus (AVPV); regions known to provide GABAergic and kisspeptin inputs to the GnRH cells. Action potential (AP) frequency was significantly higher in GnRH neurons of estrous mice than in AAS-treated or diestrous animals. No significant differences in AAS-treated, estrous or diestrous mice were evident in the amplitude or kinetics of spontaneous postsynaptic currents (sPSCs), miniature PSCs or tonic currents mediated by GABAA receptors or in GABAA receptor subunit expression in GnRH neurons. In contrast, the frequency of GABAA receptor-mediated sPSCs in GnRH neurons showed an inverse correlation with AP frequency across the three hormonal states. Surprisingly, AP activity in the medial preoptic area (mPOA), a likely source of GABAergic afferents to GnRH cells, did not vary in concert with the sPSCs in the GnRH neurons. Furthermore, pharmacological blockade of GABAA receptors did not alter the pattern in which there was lower AP frequency in GnRH neurons of AAS-treated and diestrous versus estrous mice. These data suggest that AAS do not impose their effects either directly on GnRH neurons or on putative GABAergic afferents in the mPOA. AP activity recorded from neurons in kisspeptin-rich regions of the AVPV and the expression of kisspeptin mRNA and peptide did vary coordinately with AP activity in GnRH neurons. Our data demonstrate that AAS treatment imposes a “diestrous-like” pattern of activity in GnRH neurons and suggest that this effect may arise from suppression of presynaptic kisspeptin-mediated excitatory drive arising from the AVPV. The actions of AAS on neuroendocrine regulatory circuits may contribute the disruption of reproductive function observed in steroid abuse." @default.
• W2022362978 created "2016-06-24" @default.
• W2022362978 creator A5021672075 @default.
• W2022362978 creator A5033125519 @default.
• W2022362978 creator A5069095113 @default.
• W2022362978 creator A5071873861 @default.
• W2022362978 creator A5077648220 @default.
• W2022362978 date "2011-09-01" @default.
• W2022362978 modified "2023-10-16" @default.
• W2022362978 title "Chronic exposure to anabolic androgenic steroids alters activity and synaptic function in neuroendocrine control regions of the female mouse" @default.
• W2022362978 cites W1480291593 @default.
• W2022362978 cites W1542371499 @default.
• W2022362978 cites W194722741 @default.
• W2022362978 cites W1965762896 @default.
• W2022362978 cites W1968541416 @default.
• W2022362978 cites W1971399893 @default.
• W2022362978 cites W1972669346 @default.
• W2022362978 cites W1972797102 @default.
• W2022362978 cites W1973763399 @default.
• W2022362978 cites W1974056238 @default.
• W2022362978 cites W1976995330 @default.
• W2022362978 cites W1980489982 @default.
• W2022362978 cites W1981382840 @default.
• W2022362978 cites W1981910568 @default.
• W2022362978 cites W1985312657 @default.
• W2022362978 cites W1986311333 @default.
• W2022362978 cites W1986934594 @default.
• W2022362978 cites W1990079936 @default.
• W2022362978 cites W1990355134 @default.
• W2022362978 cites W1993914855 @default.
• W2022362978 cites W1997417749 @default.
• W2022362978 cites W2001414375 @default.
• W2022362978 cites W2003975080 @default.
• W2022362978 cites W2005966256 @default.
• W2022362978 cites W2006727096 @default.
• W2022362978 cites W2009412387 @default.
• W2022362978 cites W2010070689 @default.
• W2022362978 cites W2010105282 @default.
• W2022362978 cites W2010167402 @default.
• W2022362978 cites W2011709649 @default.
• W2022362978 cites W2013920261 @default.
• W2022362978 cites W2016321438 @default.
• W2022362978 cites W2018207400 @default.
• W2022362978 cites W2018625050 @default.
• W2022362978 cites W2022625558 @default.
• W2022362978 cites W2023012283 @default.
• W2022362978 cites W2030143382 @default.
• W2022362978 cites W2030585597 @default.
• W2022362978 cites W2036628110 @default.
• W2022362978 cites W2037990673 @default.
• W2022362978 cites W2038946756 @default.
• W2022362978 cites W2042179361 @default.
• W2022362978 cites W2048683024 @default.
• W2022362978 cites W2050581082 @default.
• W2022362978 cites W2051550526 @default.
• W2022362978 cites W2051626926 @default.
• W2022362978 cites W2052757541 @default.
• W2022362978 cites W2059131332 @default.
• W2022362978 cites W2060151839 @default.
• W2022362978 cites W2060977606 @default.
• W2022362978 cites W2061896738 @default.
• W2022362978 cites W2063008992 @default.
• W2022362978 cites W2064342372 @default.
• W2022362978 cites W2065275835 @default.
• W2022362978 cites W2066627511 @default.
• W2022362978 cites W2066807389 @default.
• W2022362978 cites W2067806722 @default.
• W2022362978 cites W2072181408 @default.
• W2022362978 cites W2075545815 @default.
• W2022362978 cites W2076885783 @default.
• W2022362978 cites W2080174613 @default.
• W2022362978 cites W2081114661 @default.
• W2022362978 cites W2084173546 @default.
• W2022362978 cites W2086372530 @default.
• W2022362978 cites W2088261136 @default.
• W2022362978 cites W2094527319 @default.
• W2022362978 cites W2099249565 @default.
• W2022362978 cites W2105289833 @default.
• W2022362978 cites W2107277218 @default.
• W2022362978 cites W2108244474 @default.
• W2022362978 cites W2108895176 @default.
• W2022362978 cites W2109374960 @default.
• W2022362978 cites W2110656884 @default.
• W2022362978 cites W2110868573 @default.
• W2022362978 cites W2111824942 @default.
• W2022362978 cites W2115685512 @default.
• W2022362978 cites W2118750014 @default.
• W2022362978 cites W2123247959 @default.
• W2022362978 cites W2125450316 @default.
• W2022362978 cites W2130177841 @default.
• W2022362978 cites W2133423309 @default.
• W2022362978 cites W2136115516 @default.
• W2022362978 cites W2137582764 @default.
• W2022362978 cites W2139088926 @default.
• W2022362978 cites W2139348797 @default.
• W2022362978 cites W2139814517 @default.
• W2022362978 cites W2141607896 @default.
• W2022362978 cites W2144591770 @default.

• next