Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022363046> ?p ?o ?g. }
- W2022363046 endingPage "78" @default.
- W2022363046 startingPage "69" @default.
- W2022363046 abstract "Methacrylates are used in the polymer form as composite restorative materials in dentistry. However, the polymers can release monomers and co-monomers into the oral cavity and pulp, from where they can migrate into the bloodstream reaching virtually all organs. The local concentration of the released monomers can be in the millimolar range, high enough to induce adverse biological effects. Genotoxicity of methacrylate monomers is of a special significance due to potential serious phenotypic consequences, including cancer, and long latency period. In the present work, we investigated cytotoxicity and genotoxicity of glycidyl methacrylate (GMA) in the human peripheral blood lymphocytes and the CCR-CM human cancer cells. GMA at concentrations up to 5 mM evoked a concentration-dependent decrease in the viability of the lymphocytes up to about 80%, as assessed by flow cytometry. This agent did not induce strand breaks in the isolated plasmid DNA, but evoked concentration-dependent DNA damage in the human lymphocytes evaluated by the alkaline and neutral comet assay. This damage included oxidative modifications to the DNA bases, as checked by DNA repair enzymes Endo III and Fpg as well as single and double DNA strand breaks. The lymphocytes exposed to GMA at 2.5 μM were able to remove about 90% of damage to their DNA in 120 min. The ability of GMA to induce DNA double-strand breaks was confirmed by pulsed field gel electrophoresis. The drug evoked apoptosis and induced an increase in the G2/M cell population, accompanied by a decrease in the S cell population and an increase in G0/G1 cell population. Due to broad spectrum of GMA genotoxicity, including DNA double-strand breaks, and a potential long-lasting exposure to this compound, its use should be accompanied by precautions, reducing the chance of its release into blood stream and the possibility to induce adverse biological effects." @default.
- W2022363046 created "2016-06-24" @default.
- W2022363046 creator A5016282083 @default.
- W2022363046 creator A5023441629 @default.
- W2022363046 creator A5038319132 @default.
- W2022363046 creator A5052186294 @default.
- W2022363046 creator A5065285526 @default.
- W2022363046 creator A5070963991 @default.
- W2022363046 creator A5082137650 @default.
- W2022363046 date "2009-06-01" @default.
- W2022363046 modified "2023-09-23" @default.
- W2022363046 title "Cytotoxicity and genotoxicity of glycidyl methacrylate" @default.
- W2022363046 cites W1845321470 @default.
- W2022363046 cites W1928222724 @default.
- W2022363046 cites W1968499584 @default.
- W2022363046 cites W1969190950 @default.
- W2022363046 cites W1972528079 @default.
- W2022363046 cites W1975949258 @default.
- W2022363046 cites W1979786475 @default.
- W2022363046 cites W1993690015 @default.
- W2022363046 cites W1996037789 @default.
- W2022363046 cites W2006596417 @default.
- W2022363046 cites W2012777147 @default.
- W2022363046 cites W2014428099 @default.
- W2022363046 cites W2015500565 @default.
- W2022363046 cites W2017391462 @default.
- W2022363046 cites W2020641167 @default.
- W2022363046 cites W2023827302 @default.
- W2022363046 cites W2027509046 @default.
- W2022363046 cites W2030560888 @default.
- W2022363046 cites W2035382527 @default.
- W2022363046 cites W2035644094 @default.
- W2022363046 cites W2041683774 @default.
- W2022363046 cites W2073917908 @default.
- W2022363046 cites W2075724008 @default.
- W2022363046 cites W2078128109 @default.
- W2022363046 cites W2087536710 @default.
- W2022363046 cites W2089056264 @default.
- W2022363046 cites W2090048423 @default.
- W2022363046 cites W2090168250 @default.
- W2022363046 cites W2092629964 @default.
- W2022363046 cites W2097274883 @default.
- W2022363046 cites W2106848547 @default.
- W2022363046 cites W2121230829 @default.
- W2022363046 cites W2122809331 @default.
- W2022363046 cites W2126902508 @default.
- W2022363046 cites W2138338605 @default.
- W2022363046 cites W2160569622 @default.
- W2022363046 doi "https://doi.org/10.1016/j.cbi.2009.02.001" @default.
- W2022363046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19428346" @default.
- W2022363046 hasPublicationYear "2009" @default.
- W2022363046 type Work @default.
- W2022363046 sameAs 2022363046 @default.
- W2022363046 citedByCount "40" @default.
- W2022363046 countsByYear W20223630462012 @default.
- W2022363046 countsByYear W20223630462013 @default.
- W2022363046 countsByYear W20223630462014 @default.
- W2022363046 countsByYear W20223630462015 @default.
- W2022363046 countsByYear W20223630462017 @default.
- W2022363046 countsByYear W20223630462018 @default.
- W2022363046 countsByYear W20223630462019 @default.
- W2022363046 countsByYear W20223630462020 @default.
- W2022363046 countsByYear W20223630462022 @default.
- W2022363046 crossrefType "journal-article" @default.
- W2022363046 hasAuthorship W2022363046A5016282083 @default.
- W2022363046 hasAuthorship W2022363046A5023441629 @default.
- W2022363046 hasAuthorship W2022363046A5038319132 @default.
- W2022363046 hasAuthorship W2022363046A5052186294 @default.
- W2022363046 hasAuthorship W2022363046A5065285526 @default.
- W2022363046 hasAuthorship W2022363046A5070963991 @default.
- W2022363046 hasAuthorship W2022363046A5082137650 @default.
- W2022363046 hasConcept C109316439 @default.
- W2022363046 hasConcept C116084860 @default.
- W2022363046 hasConcept C12554922 @default.
- W2022363046 hasConcept C143425029 @default.
- W2022363046 hasConcept C153911025 @default.
- W2022363046 hasConcept C166940927 @default.
- W2022363046 hasConcept C178790620 @default.
- W2022363046 hasConcept C185592680 @default.
- W2022363046 hasConcept C190283241 @default.
- W2022363046 hasConcept C202751555 @default.
- W2022363046 hasConcept C2778959862 @default.
- W2022363046 hasConcept C2780358455 @default.
- W2022363046 hasConcept C2780801859 @default.
- W2022363046 hasConcept C2908647359 @default.
- W2022363046 hasConcept C29730261 @default.
- W2022363046 hasConcept C521977710 @default.
- W2022363046 hasConcept C53227056 @default.
- W2022363046 hasConcept C552990157 @default.
- W2022363046 hasConcept C553184892 @default.
- W2022363046 hasConcept C55493867 @default.
- W2022363046 hasConcept C71924100 @default.
- W2022363046 hasConcept C86803240 @default.
- W2022363046 hasConcept C99454951 @default.
- W2022363046 hasConceptScore W2022363046C109316439 @default.
- W2022363046 hasConceptScore W2022363046C116084860 @default.
- W2022363046 hasConceptScore W2022363046C12554922 @default.
- W2022363046 hasConceptScore W2022363046C143425029 @default.